Gastric cancer is considered to be a type of gastrointestinal tumor and is mostly
accompanied by Helicobacter pylori (HP) infection at the early stage. Hence, the long-term …

Helicobacter pylori infection of the human stomach causes chronic inflammation and forms a
major risk factor for the development of peptic ulcer disease and gastric cancer. Current …

Background Antimicrobial resistance is a global health issue that requires immediate
attention in terms of new antibiotics and new antibiotic targets. The l-lysine biosynthesis …

Flavodoxins are small soluble electron transfer proteins widely present in bacteria and
absent in vertebrates. Flavodoxins participate in different metabolic pathways and, in some …

Cholera continues to be an important public health concern in developing countries where
proper hygiene and sanitation are compromised. This severe diarrheal disease is caused by …

A new enzymatic assay for the bacterial enzyme succinyl-diaminopimelate desuccinylase
(DapE, EC 3.5. 1.18) is described. This assay employs N 6-methyl-N 2-succinyl-L, L …

Inhibitors of the bacterial enzyme dapE-encoded N-succinyl-l, l-diaminopimelic acid
desuccinylase (DapE; EC 3.5. 1.18) hold promise as antibiotics with a new mechanism of …

DapE is a Zn 2+-metallohydrolase recognized as a drug target for bacterial control. It is a
homodimer that requires the exchange of interface strands by an induced fit essential for …

We report the atomic-resolution (1.3 Å) X-ray crystal structure of an open conformation of the
dapE-encoded N-succinyl-l, l-diaminopimelic acid desuccinylase (DapE, EC 3.5. 1.18) from …

Mycobacterium avium complex (MAC) is a major cause of non-tuberculous pulmonary and
disseminated diseases worldwide, inducing bronchiectasis, and affects HIV and …