Lymphomatoid papulosis (LyP) is a very rare disease that belongs to the group of CD30+
lymphoproliferative skin diseases. LyP is localized or generalized and usually presents as …

Crohn's disease is an immune-mediated disease that results in panenteric chronic
inflammation in genetically predisposed individuals exposed to an appropriate environment …

A distinctive immunologic phenotype was demonstrated for the characteristic large atypical
cells in skin lesions of 9 patients with lymphomatoid papulosis (LP). Coexpression of …

Psoriasis is a chronic autoimmune disease which affects millions of people worldwide. Not
only can psoriasis itself be debilitating and significantly reduce an individual's quality of life …

Ustekinumab is a biological agent that is currently approved for the treatment of moderate to
severe plaque psoriasis. It is a monoclonal antibody that binds the p40 subunit of IL-12 and …

Biologics are a group of drugs that precisely affect certain specific steps in the immune
response and are an extremely useful group when used in an appropriate setting. However …

Psoriasis is a common chronic skin disorder typically characterized by erythematous
papules and plaques with a silver scale, although other presentations occur. Most cases are …

Abstract Purpose of Review The goal of this paper is to review the major adverse cutaneous
reactions that have been reported to the most commonly used biologics. Recent Findings …

DISCUSSION Biologic agents are used increasingly for psoriasis control. Among the
biologics, few cutaneous adverse events have been reported for ustekinumab and there is …

T helper (Th) cells belong to the adaptive immune system and provide an effective and
antigen-specific means of host protection. Th17 cells are a subset of Th cells, characterized …