Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …

Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle
stem cells (MuSCs). In this review, we introduce recently developed technologies and the …

Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix
components during tissue development, homeostasis, repair and disease. Despite this …

Spatial transcriptomics reveals the spatial context of gene expression, but current methods
are limited to assaying polyadenylated (A-tailed) RNA transcripts. Here we demonstrate that …

Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …

While the majority of cells contain a single nucleus, cell types such as trophoblasts,
osteoclasts, and skeletal myofibers require multinucleation. One advantage of …

Skeletal muscle possesses a remarkable regenerative capacity that relies on the activity of
muscle stem cells, also known as satellite cells. The presence of non-myogenic cells also …

Tissue regeneration declines with ageing but little is known about whether this arises from
changes in stem-cell heterogeneity. Here, in homeostatic skeletal muscle, we identify two …