MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

CONTEXT: MicroRNAs (miRNA) are noncoding RNAs that post-transcriptionally regulate
gene expression. Their altered expression and function have been observed in most …

Bone metastasis is an incurable complication of breast cancer. In advanced stages, patients
with estrogen-positive tumors experience a significantly higher incidence of bone metastasis …

The MYC oncogene codes for a transcription factor that is overexpressed in many human
cancers. Here we show that MYC regulates the expression of two immune checkpoint …

We performed genome-wide sequencing and analyzed mRNA and miRNA expression, DNA
copy number, and DNA methylation in 117 Wilms tumors, followed by targeted sequencing …

CRNDE is the gene symbol for Colorectal Neoplasia Differentially Expressed (non-protein-
coding), a long non-coding RNA (lncRNA) gene that expresses multiple splice variants and …

In Europe, almost 1000 children are diagnosed with a malignant renal tumour each year.
The vast majority of cases are nephroblastoma, also known as Wilms' tumour (WT). Most …

MicroRNAs (miRNAs) are endogenous short (20–22 nucleotides) non-coding RNA
molecules that mediate gene expression. This is an important regulatory mechanism to …

The detection of acute kidney injury (AKI) and the monitoring of chronic kidney disease
(CKD) is becoming more important in industrialized countries. Because of the direct relation …

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and
has the highest propensity to manifest as metastatic disease. Recent characterizations of the …