Quorum sensing (QS) is cell communication that is widely used by bacterial pathogens to
coordinate the expression of several collective traits, including the production of multiple …

The identification of protein disulfide isomerase, almost 50 years ago, opened the way to the
study of oxidative protein folding. Oxidative protein folding refers to the composite process …

The formation of structural disulfide bonds is essential for the function and stability of a great
number of proteins, particularly those that are secreted. There exists a variety of dedicated …

Outer membrane vesicles (OMVs) are composed of outer membrane and periplasmic
components and are ubiquitously secreted by Gram-negative bacteria. OMVs can …

Since its discovery in 1991, the bacterial periplasmic oxidative folding catalyst DsbA has
been the focus of intense research. Early studies addressed why it is so oxidizing and how it …

Abstract Three (3) Schiff bases;(E)-1-(2-nitrophenyl)-N-(o-tolyl) methanimine (1),(E)-2-
isopropyl-N-(2-nitrobenzylidene) aniline (2),(E)-2-((2-nitrobenzylidene) amino) phenol (3) …

Aims: DsbA catalyzes disulfide bond formation in secreted and outer membrane proteins in
bacteria. In pathogens, DsbA is a major facilitator of virulence constituting a target for …

Abstract Aims: The intracellular pathogen Burkholderia pseudomallei causes the disease
melioidosis, a major source of morbidity and mortality in southeast Asia and northern …

Disulfide bond formation is required for the folding of many bacterial virulence factors.
However, whereas the Escherichia coli disulfide bond-forming system is well characterized …

By catalyzing oxidative protein folding, the bacterial disulfide bond protein A (DsbA) plays an
essential role in the assembly of many virulence factors. Predictably, DsbA disruption affects …