An updated review of pro-and anti-inflammatory properties of plasma lysophosphatidylcholines in the vascular system

E Knuplez, G Marsche - International Journal of Molecular Sciences, 2020 - mdpi.com
Lysophosphatidylcholines are a group of bioactive lipids heavily investigated in the context
of inflammation and atherosclerosis development. While present in plasma during …

[HTML][HTML] Liquid biopsy in the clinical management of cancers

HY Ho, KS Chung, CM Kan, SC Wong - International Journal of Molecular …, 2024 - mdpi.com
Liquid biopsy, a noninvasive diagnosis that examines circulating tumor components in body
fluids, is increasingly used in cancer management. An overview of relevant literature …

Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers

Y Sun, X Zhang, D Hang, HCH Lau, J Du, C Liu, M Xie… - Cancer Cell, 2024 - cell.com
Changes in plasma and fecal metabolomes in colorectal cancer (CRC) progression (normal-
adenoma-CRC) remain unclear. Here, plasma and fecal samples were collected from four …

Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

JA Rothwell, J Bešević, N Dimou, M Breeur, N Murphy… - BMC medicine, 2023 - Springer
Background Amino acid metabolism is dysregulated in colorectal cancer patients; however,
it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent …

[HTML][HTML] Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations

H Yan, R Talty, A Jain, Y Cai, J Zheng, X Shen, E Muca… - Redox Biology, 2023 - Elsevier
Aberrant tumor metabolism is a hallmark of cancer in which metabolic rewiring can support
tumor growth under nutrient deficient conditions. KRAS mutations occur in 35–45% of all …

Metabolic-dysregulation-based iEESI-MS reveals potential biomarkers associated with early-stage and progressive colorectal cancer

R Zheng, R Su, F Xing, Q Li, B Liu, D Wang… - Analytical …, 2022 - ACS Publications
The application of rapid and accurate diagnostic methods can improve colorectal cancer
(CRC) survival rates dramatically. Here, we used a non-targeted metabolic analysis strategy …

[HTML][HTML] From adenoma to CRC stages: the oral-gut microbiome axis as a source of potential microbial and metabolic biomarkers of malignancy

E Russo, L Di Gloria, G Nannini, G Meoni, E Niccolai… - Neoplasia, 2023 - Elsevier
Abstract Background Approximately 95% of Colorectal cancers (CRC) consist of
adenocarcinomas originating from colonic Adenomatous polyps (AP). Increasing importance …

Circulating tryptophan metabolites and risk of colon cancer: results from case‐control and prospective cohort studies

N Papadimitriou, MJ Gunter, N Murphy… - … journal of cancer, 2021 - Wiley Online Library
Dysregulation of tryptophan metabolism has been linked to colorectal tumorigenesis;
however, epidemiological studies investigating tryptophan metabolites in relation to …

Profiling the metabolic disorder and detection of colorectal cancer based on targeted amino acids metabolomics

Y Yang, Z Wang, X Li, J Lv, R Zhong, S Gao… - Journal of Translational …, 2023 - Springer
Background The morbidity of cancer keeps growing worldwide, and among that, the
colorectal cancer (CRC) has jumped to third. Existing early screening tests for CRC are …

[HTML][HTML] Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches

EKK Lo, X Wang, PK Lee, HC Wong, JCY Lee… - Computational and …, 2023 - Elsevier
Zearalenone (ZEA), a secondary metabolite of Fusarium fungi found in cereal-based foods,
promotes the growth of colon, breast, and prostate cancer cells in vitro. However, the lack of …