Haemochromatosis is now known to be an iron-storage disease with genetic heterogeneity
but with a final common metabolic pathway resulting in inappropriately low production of the …

Virtually all living cells possess an absolute re-Ž. quirement for iron Fe, and it has been
suggested that reactions catalyzed by Fe may have constituted a wx first step in the origin of …

▪ Abstract Mammalian iron homeostasis is maintained through the concerted action of
sensory and regulatory networks that modulate the expression of proteins of iron metabolism …

Genetically hypotransferrinemic mice accumulate iron in the liver and pancreas. A similar
pattern of tissue iron accumulation occurs in humans with hereditary hemochromatosis. In …

In hemochromatosis and other disorders associated with iron overload, a significant fraction
of the total iron in plasma circulates in the form of low molecular weight complexes not …

Polyacrylamide-gel electrophoresis in urea was used to prepare the four molecular species
of transferrin: diferric transferrin, apotransferrin and the two monoferric transferrins with …

Recent evidence suggests that the hepatic iron-loading characteristic of hemochromatosis
may result in part from efficient hepatic clearance of non-transferrin-bound iron, which is …

Like the rat peritoneal macrophage, the isolated Kupffer cell is capable of processing and
releasing iron acquired by phagocytosis of immunosensitized homologous red blood cells …

In both hereditary hemochromatosis and in the various forms of secondary
hemochromatosis, there is a pathologic expansion of body iron stores due mainly to an …

Like the peritoneal macrophage, the isolated Kupffer cell is capable of processing and
releasing iron acquired by phagocytosis of immunosensitized homologous red blood cells …