Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …

Reactive astrocytes play an important role in neurological diseases, but their molecular and
functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal …

Seizures are complex pathological network events characterized by excessive and
hypersynchronized activity of neurons, including a highly diverse population of GABAergic …

Epileptic seizures are widely regarded to occur as a result of the excitation-inhibition
imbalance from a neuro-centric view. Although astrocyte-neuron interactions are …

Epilepsy is considered a circuit-level dysfunction associated with imbalanced excitation-
inhibition, it is therapeutically necessary to identify key brain regions and related circuits in …

Extracellular potassium concentration affects the membrane potential of neurons, and, thus,
neuronal activity. Indeed, alterations of potassium levels can be related to neurological …

The precise circuit of the substantia nigra pars reticulata (SNr) involved in temporal lobe
epilepsy (TLE) is still unclear. Here we found that optogenetic or chemogenetic activation of …

Objective Intracellular recordings from cells in entorhinal cortex tissue slices show that low‐
voltage fast (LVF) onset seizures are generated by inhibitory events. Here, we determined …

Epileptogenesis is the gradual process by which the healthy brain develops epilepsy.
However, the neuronal circuit changes that underlie epileptogenesis are not well …

Although cortical interneurons are apparently well-placed to suppress seizures, several
recent reports have highlighted a paradoxical role of perisomatic-targeting parvalbumin …