Genome-editing technologies have the potential to correct most genetic defects involved in
blood disorders. In contrast to mutation-specific editing, targeted gene insertion can correct …

Transcriptionally inactive genes are often positioned at the nuclear lamina (NL), as part of
large lamina‐associated domains (LADs). Activation of such genes is often accompanied by …

Understanding the packaging of DNA into chromatin has become a crucial aspect in the
study of gene regulatory mechanisms. Heterochromatin establishment and maintenance …

The folding structure of the DNA molecule combined with helper molecules, also referred to
as the chromatin, is highly relevant for the functional properties of DNA. The chromatin …

Background In most mammalian cell lines, chromatin located at the nuclear periphery is
represented by condensed heterochromatin, as evidenced by microscopy observations and …

Epigenetics is a discipline that studies potentially reversible heritable changes in gene
expression with no structural modifications in the DNA sequence. The epigenetic machinery …

The chromatin remodeling complexes chromatin accessibility complex and ATP-utilizing
chromatin assembly and remodeling factor (ACF) combine the ATPase ISWI with the …

Nucleosomes “talk” to each other about their modification state to form extended domains of
modified histones independently of the underlying DNA sequence. At the same time, DNA …

Acquired drug resistance is a major problem in the treatment of cancer. hTERT-
immortalized, untransformed RPE-1 cells can acquire resistance to Taxol by derepressing …

Insertions of transposable elements (TEs) in eukaryotic genomes are usually associated
with repressive chromatin, which spreads to neighbouring genomic sequences. In ovaries of …