In the past, metal-based compounds were widely used in the treatment of disease
conditions, but the lack of clear distinction between the therapeutic and toxic doses was a …

NAMI-A ((ImH)[trans-RuCl4 (dmso-S)(Im)], Im= imidazole) and KP1019/1339
(KP1019=(IndH)[trans-RuCl4 (Ind) 2], Ind= indazole; KP1339= Na [trans-RuCl4 (Ind) 2]) are …

As anticipated in the title, this contribution is basically divided into two, strictly connected,
parts. The first is a personal overview of the ruthenium drug candidate NAMI‐A, almost 30 …

The clinical success of platinum-based chemotherapeutic agents was of enormous impact
on the discovery of novel metal N-heterocyclic carbene (NHC) complexes as potential anti …

Two-photon excitation has attracted the attention of biologists, especially after the
development of two-photon excited microscopy in the nineties. Since then, new applications …

In this review we summarize our work on development of Ru complexes with potential
antitumor activity, which was performed over the last few years. In order to establish the …

Hypoxia severely impedes photodynamic therapy (PDT) efficiency. Worse still, considerable
tumor metastasis will occur after PDT. Herein, an organic superoxide radical (O2∙−) nano …

Ruthenium complexes exhibit a broad variety of biological and biomedical activities
including anticancer efficiency. The reason is that the octahedral bonding of both Ru (II) and …

The enzyme-mediated elevation of reactive oxygen species (ROS) at the tumor sites has
become an emerging strategy for regulating intracellular redox status for anticancer …

Studies of metal uptake, metabolism and excretion by single bacterial, yeast, plant and
animal cells is a widespread area of research, yet little is known about the reactivity and …