Resistance to therapy is the major hurdle in the current cancer management. Cancer cells
often rewire their cellular process to alternate mechanisms to resist the deleterious effect …

Bitter melon provides health benefits against various ailments for improving the quality of
life. It is nutrient dense plant-based food containing versatility of bioactive compounds such …

Background Targeted drugs are the main methods of RCC treatment. However, drug
resistance is common in RCC patients, in-depth study of the drug-resistant mechanism is …

Inflammation is the first response occurring after damage or infection, which is a defensive
process for the body. It is well known that excessive inflammation can lead to further …

Background and Objective: All-trans retinoic acid (ATRA) is only effective in acute
promyelocytic leukemia (APL), but not in other subtype of acute myeloid leukemia (AML) …

The aim of this study was to investigate how long non‑coding (lnc) RNA colon cancer‑
associated transcript 2 (CCAT2) regulates the proliferation, invasion and metastasis of …

Acute myeloid leukemia (AML) is a malignant clonal disorder affecting myeloid
differentiation through mechanisms that include epigenetic dysregulation. Abnormal …

Tyrosine kinase inhibitors (TKIs), such as imatinib (IMA) and nilotinib (NIL), are the
cornerstone of chronic myeloid leukemia (CML) treatment via the blockade of the oncogenic …

慢性粒细胞白血病作为血液系统的恶性增殖性肿瘤, 其主要发病机制为BCR-ABL1
融合基因形成, 因此针对BCR-ABL1 基因的靶向药物TKI 为其治疗带来了希望, 但TKI …

Numerous recurrent genetic mutations are known to occur in acute myeloid leukemia (AML).
Among these common mutations, Fms-like tyrosine kinase 3 remains as one of the most …