Rapid advances in high-throughput genomic technology have enabled biology to enter the
era of 'Big Data'(large datasets). The plant science community not only needs to build its …

Gene regulatory networks lie at the core of cell function control. In E. coli and S. cerevisiae,
the study of gene regulatory networks has led to the discovery of regulatory mechanisms …

Reconstructing gene regulatory networks from high-throughput data is a long-standing
challenge. Through the Dialogue on Reverse Engineering Assessment and Methods …

The reconstruction of transcriptional regulatory networks (TRNs) is a long-standing
challenge in human genetics. Numerous computational methods have been developed to …

Mapping perturbed molecular circuits that underlie complex diseases remains a great
challenge. We developed a comprehensive resource of 394 cell type–and tissue-specific …

Th17 cells have critical roles in mucosal defense and are major contributors to inflammatory
disease. Their differentiation requires the nuclear hormone receptor RORγt working with …

Transgenic crops producing insecticidal proteins from Bacillus thuringiensis (Bt) have
revolutionized control of some major pests. However, more than 25 cases of field-evolved …

Regulatory network reconstruction is a fundamental problem in computational biology.
There are significant limitations to such reconstruction using individual datasets, and …

Many eukaryotic genes possess multiple alternative promoters with distinct expression
specificities. Therefore, comprehensively annotating promoters and deciphering their …

Gene regulation is central to all aspects of organism growth, and understanding it using
large-scale functional datasets can provide a whole view of biological processes controlling …