Astrocyte heterogeneity: impact to brain aging and disease

I Matias, J Morgado, FCA Gomes - Frontiers in aging neuroscience, 2019 - frontiersin.org
Astrocytes, one of the largest glial cell population in the central nervous system (CNS), play
a key function in several events of brain development and function, such as synapse …

Catechins and their therapeutic benefits to inflammatory bowel disease

FY Fan, LX Sang, M Jiang - Molecules, 2017 - mdpi.com
Catechins are natural polyphenolic phytochemicals that exist in food and medicinal plants,
such as tea, legume and rubiaceae. An increasing number of studies have associated the …

Phytogenic compounds as alternatives to in-feed antibiotics: potentials and challenges in application

C Yang, MAK Chowdhury, Y Hou, J Gong - Pathogens, 2015 - mdpi.com
This article summarizes current experimental knowledge on the efficacy, possible
mechanisms and feasibility in the application of phytogenic products as feed additives for …

Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects

D Vauzour - Oxidative medicine and cellular longevity, 2012 - Wiley Online Library
Accumulating evidence suggests that diet and lifestyle can play an important role in delaying
the onset or halting the progression of age‐related health disorders and to improve cognitive …

Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease

RJ Williams, JPE Spencer - Free Radical Biology and Medicine, 2012 - Elsevier
There is increasing evidence that the consumption of flavonoid-rich foods can beneficially
influence normal cognitive function. In addition, a growing number of flavonoids have been …

From cocoa to chocolate: Effect of processing on flavanols and methylxanthines and their mechanisms of action

L Goya, JE Kongor, S de Pascual-Teresa - International Journal of …, 2022 - mdpi.com
Despite the health benefits associated with the ingestion of the bioactive compounds in
cocoa, the high concentrations of polyphenols and methylxanthines in the raw cocoa beans …

Natural products as a source of Alzheimer's drug leads

P Williams, A Sorribas, MJR Howes - Natural product reports, 2011 - pubs.rsc.org
Covering: up to 2010 This review focuses on recent developments in the use of natural
products as therapeutics for Alzheimer's disease. The compounds span a diverse array of …

Neuroinflammation: modulation by flavonoids and mechanisms of action

JPE Spencer, K Vafeiadou, RJ Williams… - Molecular aspects of …, 2012 - Elsevier
Neuroinflammatory processes are known to contribute to the cascade of events culminating
in the neuronal damage that underpins neurodegenerative disorders such as Parkinson's …

Comprehensive and critical view on the anti-inflammatory and immunomodulatory role of natural phenolic antioxidants

AM Pisoschi, F Iordache, L Stanca, C Cimpeanu… - European Journal of …, 2024 - Elsevier
The immune response encompasses innate and adaptive immunity, each with distinct and
specific activities. The innate immune system is constituted by phagocytic cells …

Flavanols from nature: A phytochemistry and biological activity review

Y Luo, Y Jian, Y Liu, S Jiang, D Muhammad, W Wang - Molecules, 2022 - mdpi.com
Flavanols, a common class of secondary plant metabolites, exhibit several beneficial health
properties by acting as antioxidant, anticarcinogen, cardioprotective, anti-microbial, anti …