Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGF-β)
family, are multifunctional cytokines. BMPs have a broad range of functions, and …

Bone morphogenetic proteins (BMPs) play important roles in embryonic and postnatal
development by regulating cell differentiation, proliferation, motility, and survival, thus …

Aim: To analyze the m6A methylome of osteosarcoma stem cells (OSCs). Materials &
methods: Chemoresistant OSCs were enriched by doxorubicin treatment. Expression of m6A …

Highlights•Osteosarcoma is a disease resulting from osteogenic differentiation
defects.•Differentiation therapy for osteosarcoma has received extensive attention.•Various …

Abstract Plectranthus barbatus Andrews (Lamiaceae) is widely distributed in the world and
has a range of popular therapeutic indications. This work aimed to evaluate the …

Tumor differentiation is a therapeutic strategy aimed at reactivating the endogenous
differentiation program of cancer cells and inducing cancer cells to mature and differentiate …

Ethnopharmacological relevance Traditional medicine plays a major role for primary health
care worldwide. Cancer belongs to the leading disease burden in industrialized and …

Background The putative benefit of rhBMP-2 is in the setting of limb reconstruction using
structural allografts, whether it be allograft-prosthetic composites, osteoarticular allografts, or …

The tender leaves of Rubus corchorifolius L. f. have been consumed as tea for drinking in
China since ancient times. In this study, a novel ent-kaurane diterpenoid was isolated and …

Purpose Bone Morphogenetic Protein-2 (BMP-2) may offer the potential to enhance allograft-
host osseous union in limb-salvage surgery following osteosarcoma resection. However …