Adenosine 5′-monophosphate activated protein kinase (AMPK) is a master sensor of
cellular energy status that plays a key role in the regulation of whole-body energy …

Diarylethene derivatives, the biological activity of which can be reversibly changed by
irradiation with light of different wavelengths, have shown promise as scientific tools and as …

Abstract α‐and β‐Cyclodextrins have been used as scaffolds for the synthesis of six‐and
seven‐legged templates by functionalizing every primary CH2OH with a 4‐pyridyl moiety …

Analogs of the known inhibitor (peptide pDI) of the p53/MDM2 protein–protein interaction
are reported, which are stapled by linkers bearing a photoisomerizable diarylethene moiety …

Protein–protein interactions that have large, flat and featureless binding sites are difficult
drug targets. In the development of their modulators conventional drug discovery strategies …

We synthesized a library of aminopyrazole analogs to systematically explore the
hydrophobic pocket adjacent to the hinge region and the solvent exposed region of cyclin …

Understanding mechanisms of protein folding and binding is crucial to designing their
molecular function. Molecular dynamics (MD) simulations and Markov state model (MSM) …

Using model peptide β-hairpin scaffolds, the facile formation of a remarkably stable
covalently cross-linked modification is reported in the tryptophan side chain, which confers …

Genetic models validated Inhibitor of nuclear factor (NF) kappa B kinase beta (IKKβ) as a
therapeutic target for KRAS mutation associated pancreatic cancer. Phosphorylation of the …

Peptides are promising therapeutic agents for various biological targets due to their high
efficacy and low toxicity, and the design of peptide ligands with high binding affinity to the …