Autophagy is a highly conserved catabolic process and participates in a variety of cellular
biological activities. The phosphoinositide 3-kinase (PI3K)/protein kinase B …

Viral infections and outbreaks have become a major concern and are one of the main
causes of morbidity and mortality worldwide. The development of successful antiviral …

Hepatocellular carcinoma (HCC) has become one of the major diseases that are threatening
human health in the 21st century. Currently there are many approaches to treat liver cancer …

The development of new effective anti-coronavirus drugs and therapies is important, but it
requires significant human, financial and, most importantly, time expenditures. The current …

A major challenge to achieving industry-scale biomanufacturing of therapeutic alkaloids is
the slow process of biocatalyst engineering. Amaryllidaceae alkaloids, such as the …

Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus
and no effective therapy is approved. Here, lycorine, a natural alkaloid, was identified as a …

Background Topical anticancer drugs offer a potential therapeutic modality with high
compliance for treating cutaneous squamous cell carcinoma (cSCC). However, the existing …

Indolizidine alkaloids are chemical constituents isolated from various marine and terrestrial
plants and animals, including but not limited to trees, fungi, ants, and frogs, with a myriad of …

Abstract Di-(2-ethylhexyl) phthalate (DEHP), an extensively used plasticizer, can cause
environmental pollution and organ injury. Lycopene (LYC) is a natural carotene that has the …

Background Multiorgan dysfunction, especially sepsis-related multiorgan damage, remains
a major cause of high mortality in the late stages of infection and a great clinical challenge …