Cannabis sativa L. Bioactive Compounds and Their Protective Role in Oxidative Stress and Inflammation

DM Kopustinskiene, R Masteikova, R Lazauskas… - Antioxidants, 2022 - mdpi.com
Cannabis (Cannabis sativa L.) plants from the family Cannabidaceae have been used since
ancient times, to produce fibers, oil, and for medicinal purposes. Psychoactive delta-9 …

Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies

P Sharma, P Srivastava, A Seth, PN Tripathi… - Progress in …, 2019 - Elsevier
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease

G Watt, T Karl - Frontiers in pharmacology, 2017 - frontiersin.org
Alzheimer's disease (AD) is a debilitating neurodegenerative disease that is affecting an
increasing number of people. It is characterized by the accumulation of amyloid-β and tau …

The endocannabinoid system as an emerging target of pharmacotherapy

P Pacher, S Bátkai, G Kunos - Pharmacological reviews, 2006 - ASPET
The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

J Fernández‐Ruiz, O Sagredo… - British journal of …, 2013 - Wiley Online Library
Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties for numerous
disorders exerted through molecular mechanisms that are yet to be completely identified …

Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation

BG Ramírez, C Blázquez, TG Del Pulgar… - Journal of …, 2005 - Soc Neuroscience
Alzheimer9s disease (AD) is characterized by enhanced β-amyloid peptide (βA) deposition
along with glial activation in senile plaques, selective neuronal loss, and cognitive deficits …

[图书][B] Pharmacological actions of cannabinoids

RG Pertwee - 2005 - Springer
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Cannabinoid receptor 2 signaling in neurodegenerative disorders: from pathogenesis to a promising therapeutic target

T Cassano, S Calcagnini, L Pace, F De Marco… - Frontiers in …, 2017 - frontiersin.org
As a consequence of an increasingly aging population, the number of people affected by
neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and …

A systematic review of minor phytocannabinoids with promising neuroprotective potential

NL Stone, AJ Murphy, TJ England… - British Journal of …, 2020 - Wiley Online Library
Embase and PubMed were systematically searched for articles addressing the
neuroprotective properties of phytocannabinoids, apart from cannabidiol and Δ9 …

Neuroprotective effect of cannabidiol, a non‐psychoactive component from Cannabis sativa, on β‐amyloid‐induced toxicity in PC12 cells

T Iuvone, G Esposito, R Esposito… - Journal of …, 2004 - Wiley Online Library
Alzheimer's disease is widely held to be associated with oxidative stress due, in part, to the
membrane action of β‐amyloid peptide aggregates. Here, we studied the effect of …