A guide to the composition and functions of the extracellular matrix

NK Karamanos, AD Theocharis, Z Piperigkou… - The FEBS …, 2021 - Wiley Online Library
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Therapeutic targets in lung tissue remodelling and fibrosis

G Liu, AM Philp, T Corte, MA Travis, H Schilter… - Pharmacology & …, 2021 - Elsevier
Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

COVID-19: immunohistochemical analysis of TGF-β signaling pathways in pulmonary fibrosis

CB Vaz de Paula, S Nagashima, V Liberalesso… - International journal of …, 2021 - mdpi.com
Acute respiratory distress syndrome (ARDS) followed by repair with lung remodeling is
observed in COVID-19. These findings can lead to pulmonary terminal fibrosis, a form of …

Research progress in the molecular mechanisms, therapeutic targets, and drug development of idiopathic pulmonary fibrosis

H Ma, X Wu, Y Li, Y Xia - Frontiers in Pharmacology, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Recent studies have
identified the key role of crosstalk between dysregulated epithelial cells, mesenchymal …

Pulmonary fibrosis from molecular mechanisms to therapeutic interventions: lessons from post-COVID-19 patients

C Giacomelli, R Piccarducci, L Marchetti… - Biochemical …, 2021 - Elsevier
Pulmonary fibrosis (PF) is characterised by several grades of chronic inflammation and
collagen deposition in the interalveolar space and is a hallmark of interstitial lung diseases …

Collagen remodeling along cancer progression providing a novel opportunity for cancer diagnosis and treatment

K Song, Z Yu, X Zu, G Li, Z Hu, Y Xue - International Journal of Molecular …, 2022 - mdpi.com
The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …

UHRF1-mediated ferroptosis promotes pulmonary fibrosis via epigenetic repression of GPX4 and FSP1 genes

Y Liu, D Cheng, Y Wang, S Xi, T Wang, W Sun… - Cell Death & …, 2022 - nature.com
Pulmonary fibrosis (PF), as an end-stage clinical phenotype of interstitial lung diseases
(ILDs), is frequently initiated after alveolar injury, in which ferroptosis has been identified as …

Multiscale modeling of lung mechanics: from alveolar microstructure to pulmonary function

DE Hurtado, N Avilés-Rojas, F Concha - … of the Mechanics and Physics of …, 2023 - Elsevier
The mechanical behavior of the lungs has long been associated with the structural
properties of alveoli in pulmonary medicine. However, this structure-function relationship …

Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy

Y Xu, L Ying, JK Lang, B Hinz, R Zhao - Science Advances, 2024 - science.org
Pulmonary fibrosis is an often fatal lung disease. Immune cells such as macrophages were
shown to accumulate in the fibrotic lung, but their contribution to the fibrosis development is …

Modulating Fibrotic Mechanical Microenvironment for Idiopathic Pulmonary Fibrosis Therapy

XN Li, YP Lin, MM Han, YF Fang, L Xing… - Advanced …, 2024 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is exacerbated by injurious mechanical forces that
destabilize the pulmonary mechanical microenvironment homeostasis, leading to alveolar …