Renal fibrosis is the common pathway for most forms of progressive renal disease. The
Unilateral Ureteral Obstruction (UUO) model is used to cause renal fibrosis, where the …

Renal fibrosis is the hallmark of progressive renal disease of virtually any etiology. The
model of unilateral ureteral obstruction (UUO) in the rodent generates progressive renal …

Congenital obstructive nephropathy accounts for the greatest fraction of chronic kidney
disease in children. Genetic and nongenetic factors responsible for the lesions are largely …

Tissue-type plasminogen activator (tPA) is one of the major components in the matrix
proteolytic network whose role in the pathogenesis of renal interstitial fibrosis remains …

Unilateral ureteral obstruction (UUO) is a model of renal injury characterized by progressive
tubulointerstitial fibrosis and renal damage, while relatively sparing the glomerulus and not …

Obstructive nephropathy is a major cause of renal failure, particularly in infants and children.
Cellular and molecular mechanisms responsible for the progression of the tubular atrophy …

Hypertension and chronic kidney disease (CKD) have a significant impact on global
morbidity and mortality. The Low Birth Weight and Nephron Number Working Group has …

Chronic kidney disease constitutes an increasing medical burden affecting 26 million people
in the United States alone. Diabetes, hypertension, ischemia, acute injury, and urological …

Tubular atrophy and interstitial fibrosis, important in progression of renal diseases, including
diabetic (D) and cyclosporine-induced (CSA) nephropathy, have been considered …

The renal response to urinary tract obstruction is complex and involves a wide array of
interacting molecules. Elucidation of these interactions will lead to the identification of …