Fracture of bone disrupts its circulation and leads to necrosis and hypoxia of adjacent bone.
Under normal circumstances, fractured bone undergoes the orderly regeneration of its …

The early-gestation fetus heals dermal wounds rapidly and scarlessly. This phenomenon
appears to be intrinsic to fetal skin and independent of the intrauterine environment. Unique …

This textbook describes the basic principles of induced organ regeneration in skin and
peripheral nerves and extends the original successful paradigm to other organs. A set of …

Tendon injuries account for a significant number of musculoskeletal afflictions each year.
While new surgical techniques and rehabilitation protocols have led to improved clinical …

The ability of a fetus to heal without scar formation depends on its gestational age at the time
of injury and the size of the wound defect. In general, linear incisions heal without scar until …

Skin wounds in young embryos heal rapidly, efficiently and perfectly without scar formation,
an ability that is lost as development proceeds. The tissue movements of repair (re …

Studies of contemporary populations have demonstrated an association between decreased
dietary diversity due to resource scarcity or underutilization and an increase in diseases …

In mature skin, wound repair typically begins with hemostasis and inflammation. This is
followed by a proliferative phase with reepithelialization, angiogenesis, and collagen …

Scarless healing of cutaneous wounds occurs in humans during the first two trimesters of
development, but by birth all wounds are repaired with scar formation. To search for …

Safety, quality, and regulatory-driven iterative optimization of therapeutic cell source
selection has constituted the core developmental bedrock for primary fetal progenitor cell …