Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …

A phenomenon known for over 100 years named “cell-in-cell”(CIC) is now undergoing its
renaissance, mostly due to modern cell visualization techniques. It is no longer an esoteric …

Liver cirrhosis is a liver disease with a high mortality rate worldwide, and antifibrotic drugs
are commonly used clinically to alleviate the symptoms, but there are still many challenges …

Background & Aims The liver plays crucial roles in the regulation of immune defense during
acute systemic infections. However, the roles of liver cellular clusters and intercellular …

The presence of CD8+ T cells in the cytoplasm of biliary epithelial cells (BEC) has been
correlated with biliary damage associated with primary biliary cholangitis (PBC). Here, we …

Acute liver injury (ALI), often caused by viruses, alcohol, drugs, etc., is one of the most
common clinical liver diseases. Although pyroptosis plays an important role in ALI, there is …

Abstract Ethnopharmacological relevance Although the Traditional Chinese Medicine (TCM)
prescription of Danggui Shaoyao San (DSS) presents substantial clinical efficacy and …

The liver, the largest organ in the human body, plays a multifaceted role in digestion,
coagulation, synthesis, metabolism, detoxification, and immune defense. Changes in liver …

The liver is an immune organ that plays a vital role in the detection, capture, and clearance
of pathogens and foreign antigens that invade the human body. During acute and chronic …

Herein we analyze two special routes of the multinucleated cells' formation–the fusion of
mononuclear cells and the formation of cell-in-cell structures–in the healthy tissues and in …