Macrophages: the good, the bad, and the gluttony

EA Ross, A Devitt, JR Johnson - Frontiers in immunology, 2021 - frontiersin.org
Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

New insights into the role of antinuclear antibodies in systemic lupus erythematosus

DS Pisetsky, PE Lipsky - Nature Reviews Rheumatology, 2020 - nature.com
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by
antinuclear antibodies (ANAs) that form immune complexes that mediate pathogenesis by …

[HTML][HTML] The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

J Friščić, M Böttcher, C Reinwald, H Bruns, B Wirth… - Immunity, 2021 - cell.com
Arthritis typically involves recurrence and progressive worsening at specific predilection
sites, but the checkpoints between remission and persistence remain unknown. Here, we …

Immunogenicity of recombinant adeno-associated virus (AAV) vectors for gene transfer

M Arjomandnejad, I Dasgupta, TR Flotte, AM Keeler - BioDrugs, 2023 - Springer
Recombinant adeno-associated viruses (AAVs) have emerged as promising gene delivery
vehicles resulting in three US Food and Drug Administration (FDA) and one European …

Overcoming innate immune barriers that impede AAV gene therapy vectors

M Muhuri, Y Maeda, H Ma, S Ram… - The Journal of …, 2021 - Am Soc Clin Investig
The field of gene therapy has made considerable progress over the past several years.
Adeno-associated virus (AAV) vectors have emerged as promising and attractive tools for in …

Complement receptors and their role in leukocyte recruitment and phagocytosis

S Vandendriessche, S Cambier, P Proost… - Frontiers in Cell and …, 2021 - frontiersin.org
The complement system is deeply embedded in our physiology and immunity. Complement
activation generates a multitude of molecules that converge simultaneously on the …

Clinical and immunological biomarkers for systemic lupus erythematosus

H Yu, Y Nagafuchi, K Fujio - Biomolecules, 2021 - mdpi.com
Systemic lupus erythematosus (SLE) is characterized by immune system dysfunction and is
clinically heterogeneous, exhibiting renal, dermatological, neuropsychiatric, and …

Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission

S Tasaki, K Suzuki, Y Kassai, M Takeshita… - Nature …, 2018 - nature.com
Sustained clinical remission (CR) without drug treatment has not been achieved in patients
with rheumatoid arthritis (RA). This implies a substantial difference between CR and the …

[HTML][HTML] Коронавирусная болезнь 2019 (COVID-19) и иммуновоспалительные ревматические заболевания. Рекомендации Общероссийской общественной …

ЕЛ Насонов, АМ Лила, ВИ Мазуров… - Научно …, 2021 - cyberleninka.ru
В середине 2021 года инфекция SARS-CoV-2 (Severe Acute Respiratory coronavirus 2),
вызвавшая пандемию коронавирусной болезни 2019 (coronavirus disease, COVID-19) …

Multisystem inflammatory syndrome and autoimmune diseases following COVID-19: molecular mechanisms and therapeutic opportunities

P Hosseini, MS Fallahi, G Erabi, M Pakdin… - Frontiers in molecular …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-
coronavirus 2 (SARS-CoV-2), has led to huge concern worldwide. Some SARS-CoV-2 …