Fascin actin-bundling protein 1 in human cancer: promising biomarker or therapeutic target?
H Liu, Y Zhang, L Li, J Cao, Y Guo, Y Wu… - Molecular Therapy …, 2021 - cell.com
Fascin actin-bundling protein 1 (FSCN1) is a highly conserved actin-bundling protein that
cross links F-actin microfilaments into tight, parallel bundles. Elevated FSCN1 levels have …
cross links F-actin microfilaments into tight, parallel bundles. Elevated FSCN1 levels have …
How does fascin promote cancer metastasis?
Fascin is an F‐actin‐bundling protein that cross‐links individual actin filaments into straight
and stiff bundles. Fascin overexpression in cancer is strongly associated with poor …
and stiff bundles. Fascin overexpression in cancer is strongly associated with poor …
[HTML][HTML] FSCN1 acts as a promising therapeutic target in the blockade of tumor cell motility: a review of its function, mechanism, and clinical significance
Z Li, J Shi, N Zhang, X Zheng, Y Jin, S Wen… - Journal of …, 2022 - ncbi.nlm.nih.gov
Fascin actin-bundling protein 1 (FSCN1) is an actin-bundling protein that is capable of
inducing membrane protrusions and plays critical roles in cell migration, motility, adhesion …
inducing membrane protrusions and plays critical roles in cell migration, motility, adhesion …
The FDA-approved antiviral raltegravir inhibits fascin1-dependent invasion of colorectal tumor cells in vitro and in vivo
B Alburquerque-González, Á Bernabé-García… - Cancers, 2021 - mdpi.com
Simple Summary Colorectal cancer (CRC) is the third leading cause of cancer-related
deaths worldwide. Serrated adenocarcinoma (SAC) has been recently recognized by the …
deaths worldwide. Serrated adenocarcinoma (SAC) has been recently recognized by the …
Zebrafish xenograft as a tool for the study of colorectal cancer: a review
CM Fontana, H Van Doan - Cell Death & Disease, 2024 - nature.com
Colorectal cancer (CRC) is the second leading cause of cancer-related death, mostly due to
metastatic disease and the fact that many patients already show signs of metastasis at the …
metastatic disease and the fact that many patients already show signs of metastasis at the …
Fascin-1 in cancer cell metastasis: old target-new insights
E Sarantelli, A Mourkakis, LC Zacharia… - International Journal of …, 2023 - mdpi.com
As metastasis is responsible for most cancer-related deaths, understanding the cellular and
molecular events that lead to cancer cell migration and invasion will certainly provide …
molecular events that lead to cancer cell migration and invasion will certainly provide …
Antitumoral effects of tricyclic antidepressants: beyond neuropathic pain treatment
A Asensi-Cantó, MD López-Abellán… - Cancers, 2022 - mdpi.com
Simple Summary Tricyclic antidepressants (TCAs) are old and known therapeutic agents
whose good safety profile makes them good candidates for drug repurposing. As the …
whose good safety profile makes them good candidates for drug repurposing. As the …
Emerging role of fascin-1 in the pathogenesis, diagnosis, and treatment of the gastrointestinal cancers
Simple Summary Gastrointestinal (GI) cancers, including esophageal, gastric, colorectal,
liver, and pancreatic cancers, remain as one of the leading causes of death worldwide, with …
liver, and pancreatic cancers, remain as one of the leading causes of death worldwide, with …
Fascin in gynecological cancers: an update of the literature
Simple Summary Fascin, an actin-binding protein, is upregulated in different types of human
cancers. It is reportedly responsible for increasing the invasive and metastatic ability of …
cancers. It is reportedly responsible for increasing the invasive and metastatic ability of …
Fascin inhibitors decrease cell migration and adhesion while increase overall survival of mice bearing bladder cancers
Z Zhao, Y Wang, JJ Zhang, XY Huang - Cancers, 2021 - mdpi.com
Simple Summary Fascin is an actin-bundling protein, and is highly expressed in metastatic
tumor cells. Small molecule fascin inhibitors have been recently developed to block tumor …
tumor cells. Small molecule fascin inhibitors have been recently developed to block tumor …