Fasciolosis caused by the liver flukes Fasciola hepatica and Fasciola gigantica is one of the
most important neglected parasitic diseases of humans and animals. The ability of the …

Helminths (worms) are one of the most successful organisms in nature given their ability to
infect millions of humans and animals worldwide. Their success can be attributed to their …

Background The major pathogenesis associated with Fasciola hepatica infection results
from the extensive tissue damage caused by the tunnelling and feeding activity of immature …

Fasciolosis caused by trematode parasites of the genus Fasciola is a global disease of
livestock, particularly cattle, sheep, water buffalo and goats. It is also a major human …

In the past decade significant advances in our understanding of liver fluke biology have
been made through in-depth interrogation and analysis of evolving Fasciola hepatica and …

The liver fluke Fasciola hepatica is an economically important pathogen of livestock
worldwide, as well as being an important neglected zoonosis. Parasite control is reliant on …

Kunitz-type domains are ubiquitously found in natural systems as serine protease inhibitors
or animal toxins in venomous animals. Kunitz motif is a cysteine-rich peptide chain of~ 60 …

Serine protease inhibitors (serpins) regulate proteolytic events within diverse biological
processes, including digestion, coagulation, inflammation and immune responses. The …

Fasciola hepatica is a global parasite of humans and their livestock. Regulation of parasite-
secreted cathepsin L-like cysteine proteases associated with virulence is important to fine …

The liver fluke Fasciola hepatica is an economically important global pathogen of humans
and their livestock. To facilitate host invasion and migration, F. hepatica secretes an …