ATP-dependent severing of microtubules was first reported in Xenopus laevis egg extracts in
1991. Two years later this observation led to the purification of the first known microtubule …

The mitotic spindle accurately segregates genetic instructions by moving chromosomes to
spindle poles (anaphase A) and separating the poles (anaphase B) so that, in general, the …

Tubulin assembles into microtubule polymers that have distinct plus and minus ends. Most
microtubule plus ends in living cells are dynamic; the transitions between growth and …

The causal gene of a novel small and round seed mutant phenotype (srs3) in rice was
identified by map-based cloning and named the SRS3 gene. The SRS3 gene was grouped …

Regulation of microtubule dynamics at the cell cortex is important for cell motility,
morphogenesis and division. Here we show that the Drosophila katanin Dm-Kat60 functions …

The separation of sister chromatids during anaphase is the culmination of mitosis and one of
the most strikingly beautiful examples of cellular movement. It consists of two distinct …

Summary Background Sperm length in Drosophilidae varies from a few hundred microns to
6 cm as a result of evolutionary selection. In postcopulatory competition, longer sperm have …

Fidgetin is a member of the AAA protein superfamily with important roles in mammalian
development. Here we show that human Fidgetin is a potent microtubule severing and …

The mitotic spindle is a bipolar cellular structure, built from tubulin polymers, called
microtubules, and interacting proteins. This macromolecular machine orchestrates …

The mitotic spindle uses dynamic microtubules and mitotic motors to generate the pico-
Newton scale forces that are needed to drive the mitotic movements that underlie …