Alzheimer's disease (AD) is characterized by two major pathological lesions in the brain,
amyloid plaques and neurofibrillary tangles (NFTs) composed mainly of amyloid-β (Aβ) …

Proteinopathy and excessive production of reactive oxygen species (ROS), which are the
principal features observed in the Alzheimer's disease (AD) brain, contribute to neuronal …

Both the replication of protein aggregates and their spreading throughout the brain are
implicated in the progression of Alzheimer's disease (AD). However, the rates of these …

Tau is a protein that associates with microtubules (MTs) and promotes their assembly and
stability. The protein loses its ability to bind MTs in tauopathies, and detached tau can …

Oligomers which form during amyloid fibril assembly are considered to be key contributors
towards amyloid disease. However, understanding how such intermediates form, their …

The spontaneous assembly of proteins into amyloid fibrils is a phenomenon central to many
increasingly common and currently incurable human disorders, including Alzheimer's and …

Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …

Fibrillar protein aggregates are a hallmark of a range of human disorders, from prion
diseases to dementias, but are also encountered in several functional contexts. Yet, the …

The misfolding of proteins is now recognized to be the origin of a large number of medical
disorders. One particularly important group of such disorders is associated with the …

Soluble aggregates of the microtubule-associated protein tau have been challenging to
assemble and characterize, despite their important role in the development of tauopathies …