Epithelial cell–derived cytokines: more than just signaling the alarm
F Roan, K Obata-Ninomiya… - The Journal of clinical …, 2019 - Am Soc Clin Investig
The epithelial cell–derived cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25
are central regulators of type 2 immunity, which drives a broad array of allergic responses …
are central regulators of type 2 immunity, which drives a broad array of allergic responses …
The immunology of asthma
BN Lambrecht, H Hammad - Nature immunology, 2015 - nature.com
Asthma is a common disease that affects 300 million people worldwide. Given the large
number of eosinophils in the airways of people with mild asthma, and verified by data from …
number of eosinophils in the airways of people with mild asthma, and verified by data from …
Early local immune defences in the respiratory tract
The respiratory immune response consists of multiple tiers of cellular responses that are
engaged in a sequential manner in order to control infections. The stepwise engagement of …
engaged in a sequential manner in order to control infections. The stepwise engagement of …
TH2, allergy and group 2 innate lymphoid cells
The initiation of type 2 immune responses by the epithelial cell–derived cytokines IL-25, IL-
33 and TSLP has been an area of extensive research in the past decade. Such studies have …
33 and TSLP has been an area of extensive research in the past decade. Such studies have …
The development and in vivo function of T helper 9 cells
The specialized cytokine secretion profiles of T helper (TH) cells are the basis for a focused
and efficient immune response. On the twentieth anniversary of the first descriptions of the …
and efficient immune response. On the twentieth anniversary of the first descriptions of the …
IL-9-producing T cells: potential players in allergy and cancer
P Angkasekwinai, C Dong - Nature Reviews Immunology, 2021 - nature.com
Abstract IL-9-producing CD4+ T cells have been considered to represent a distinct T helper
cell (TH cell) subset owing to their unique developmental programme in vitro, their …
cell (TH cell) subset owing to their unique developmental programme in vitro, their …
Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation
R Divekar, H Kita - Current opinion in allergy and clinical …, 2015 - journals.lww.com
Summary TSLP, IL-25, and IL-33 are increasingly recognized to play important roles in the
pathophysiology of allergic diseases. More clear recognition of the differences and …
pathophysiology of allergic diseases. More clear recognition of the differences and …
An IL-9–pulmonary macrophage axis defines the allergic lung inflammatory environment
Despite IL-9 functioning as a pleiotropic cytokine in mucosal environments, the IL-9–
responsive cell repertoire is still not well defined. Here, we found that IL-9 mediates …
responsive cell repertoire is still not well defined. Here, we found that IL-9 mediates …
Th9 cell development requires a BATF-regulated transcriptional network
T helper 9 (Th9) cells are specialized for the production of IL-9, promote allergic
inflammation in mice, and are associated with allergic disease in humans. It has not been …
inflammation in mice, and are associated with allergic disease in humans. It has not been …
Th9 cells, new players in adaptive immunity
Upon antigen-specific stimulation, naïve CD4+ T cells have the potential to differentiate into
various T helper (Th) cell subsets. Earlier models of Th cell differentiation focused on IFN-γ …
various T helper (Th) cell subsets. Earlier models of Th cell differentiation focused on IFN-γ …