Iron overload is a risk factor for diabetes. The link between iron and diabetes was first
recognized in pathologic conditions—hereditary hemochromatosis and thalassemia—but …

The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling
processes that are critical for differentiation and proliferation. Not surprisingly, loss of …

Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …

Most malignant cells display increased glucose absorption and metabolism compared to
surrounding tissues. This well-described phenomenon results from a metabolic …

Chromatin-remodeling enzymes play essential roles in many biological processes, including
gene expression, DNA replication and repair, and cell division. Although one such complex …

Iron fine-tunes innate immune responses, including macrophage inflammation. In this
review, we summarize the current understanding about the iron in dictating macrophage …

Eukaryotes have evolved multiple ATP-dependent chromatin remodelers to shape the
nucleosome landscape. We recently uncovered an evolutionarily conserved SWItch/Sucrose …

Over millions of years, eukaryotes evolved from unicellular to multicellular organisms with
increasingly complex genomes and sophisticated gene expression networks. Consequently …

There is a close relationship between histone acetylation and ATP-dependent chromatin
remodeling that is not fully understood. We show that acetylation of histone H3 tails affects …

Most cellular processes are conducted by multi-protein complexes. However, little is known
about how these complexes are assembled. In particular, it is not known if they are formed …