The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …

The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …

Abstract Src homology 3 (SH3) domains are involved in the regulation of important cellular
pathways, such as cell proliferation, migration and cytoskeletal modifications. Recognition of …

The PDZ domain is a protein–protein interacting module that plays an important role in the
organization of signaling complexes. The recognition of short intrinsically disordered C …

Self-binding peptides (SBPs) represent those short peptide segments within monomeric
proteins to fulfill their biological functions by dynamically binding to/unbinding from their …

The canonical binding mode of PDZ domains to target motifs involves a small interface,
unlikely to fully account for PDZ-target interaction specificities. Here, we review recent work …

Self-binding peptides (SBPs) represent a novel biomolecular phenomenon spanning
between folding and binding, where a short peptide segment within a monomeric protein …

Viruses interact extensively with host proteins, but the mechanisms controlling these
interactions are not well understood. We present a comprehensive analysis of eukaryotic …

Short linear motifs (SLiMs) are protein interaction sites that play an important role in cell
regulation by controlling protein activity, localization, and local abundance. The functionality …

Highlights•Accrual of peptide–protein complex structures allowed their detailed
characterization.•This has lead to rapid progress in peptide docking, based on diverse …