Lipids and lipid derivatives for RNA delivery

Y Zhang, C Sun, C Wang, KE Jankovic… - Chemical reviews, 2021 - ACS Publications
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery

M Maeki, S Uno, A Niwa, Y Okada, M Tokeshi - Journal of Controlled …, 2022 - Elsevier
In 2021, mRNA vaccines against COVID-19 were approved by the Food and Drug
Administration. mRNA vaccines are important for preventing severe COVID-19 and returning …

Microfluidic nanoparticles for drug delivery

Y Liu, G Yang, Y Hui, S Ranaweera, CX Zhao - Small, 2022 - Wiley Online Library
Nanoparticles (NPs) have attracted tremendous interest in drug delivery in the past decades.
Microfluidics offers a promising strategy for making NPs for drug delivery due to its capability …

Clinical translation of nanomedicines: Challenges, opportunities, and keys

MA Younis, HM Tawfeek, AAH Abdellatif… - Advanced drug delivery …, 2022 - Elsevier
Despite the massive interest and recent developments in the field of nanomedicine, only a
limited number of formulations have found their way to the clinics. This shortcoming reveals …

Liposomes: Advancements and innovation in the manufacturing process

S Shah, V Dhawan, R Holm, MS Nagarsenker… - Advanced drug delivery …, 2020 - Elsevier
Liposomes are well recognised as effective drug delivery systems, with a range of products
approved, including follow on generic products. Current manufacturing processes used to …

Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines

T Nakamura, Y Sato, Y Yamada… - Advanced drug delivery …, 2022 - Elsevier
A new era of nanomedicines that involve nucleic acids/gene therapy has been opened after
two decades in 21st century and new types of more efficient drug delivery systems (DDS) …

A comprehensive review on recent preparation techniques of liposomes

C Has, P Sunthar - Journal of liposome research, 2020 - Taylor & Francis
Liposomes (or lipid vesicles) are a versatile platform as carriers for the delivery of the drugs
and other macromolecules into human and animal bodies. Though the method of using …

Lipid nanoparticle-mediated drug delivery to the brain

P Khare, SX Edgecomb, CM Hamadani… - Advanced Drug Delivery …, 2023 - Elsevier
Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their
applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech …

Microfluidic vortex focusing for high throughput synthesis of size-tunable liposomes

JY Han, JN La Fiandra, DL DeVoe - Nature communications, 2022 - nature.com
Control over vesicle size during nanoscale liposome synthesis is critical for defining the
pharmaceutical properties of liposomal nanomedicines. Microfluidic technologies capable of …

Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems

M Maeki, N Kimura, Y Sato, H Harashima… - Advanced drug delivery …, 2018 - Elsevier
Lipid-based nanobiomaterials as liposomes and lipid nanoparticles (LNPs) are the most
widely used nanocarriers for drug delivery systems (DDSs). Extracellular vesicles (EVs) and …