New anticonvulsant agents

B Malawska - Frontiers in Medicinal Chemistry: Volume 4, 2009 - benthamdirect.com
The search for antiepileptic compounds with more selective activity and lower toxicity
continues to be an area of intensive investigation in medicinal chemistry. This review …

A Comprehensive survey on the expediated anti-COVID-19 options enabled by metal complexes—Tasks and trials

J Gopal, M Muthu, I Sivanesan - Molecules, 2023 - mdpi.com
Contemporary pharmacology dating back to the late 19th/early 20th centuries has benefitted
largely from the incorporation of metal complexes. Various biological attributes have been …

Triazole incorporated thiazoles as a new class of anticonvulsants: Design, synthesis and in vivo screening

N Siddiqui, W Ahsan - European journal of medicinal chemistry, 2010 - Elsevier
Various 3-[4-(substituted phenyl)-1, 3-thiazol-2-ylamino]-4-(substituted phenyl)-4, 5-dihydro-
1H-1, 2, 4-triazole-5-thiones (7a–t) were designed keeping in view the structural …

Synthesis, anticonvulsant activity and 3D-QSAR study of some prop-2-eneamido and 1-acetyl-pyrazolin derivatives of aminobenzothiazole

ND Amnerkar, KP Bhusari - European Journal of Medicinal Chemistry, 2010 - Elsevier
A series of 6-substituted-[3-substituted-prop-2-eneamido] benzothiazole 9–32 and 6-
substituted-2-[(1-acetyl-5-substituted)-2-pyrazolin-3-yl] aminobenzothiazole 33–56 were …

N'-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl) methylene] 2/4-substituted hydrazides: Synthesis and anticonvulsant activity

D Kaushik, SA Khan, G Chawla, S Kumar - European Journal of Medicinal …, 2010 - Elsevier
A series of N'-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl) methylene] 2/4-substituted
hydrazides were synthesized using appropriate synthetic route and characterized by …

Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents

KM Amin, DEA Rahman, YA Al-Eryani - Bioorganic & medicinal chemistry, 2008 - Elsevier
Some new substituted coumarinylthiazolines, coumarinylthiazolidin-4-ones, and substituted
chromenothiazoles were synthesized and evaluated for anticonvulsant activity. Some …

Synthesis of benzothiazole semicarbazones as novel anticonvulsants—The role of hydrophobic domain

N Siddiqui, A Rana, SA Khan, MA Bhat… - Bioorganic & medicinal …, 2007 - Elsevier
A series of 1, 3-benzothiazol-2-yl semicarbazones (1–15) were prepared in satisfactory yield
and evaluated for their anticonvulsant, neurotoxicity and other toxicity studies. All the …

Novel platinum (II) and palladium (II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic …

A Karaküçük-İyidoğan, D Taşdemir… - European journal of …, 2011 - Elsevier
A series of thiosemicarbazones and their platinum (II) and palladium (II) complexes have
been synthesized. The chemical structures of ligands and their complexes were …

Synthesis, characterization and anticancer activity of new 2-acetyl-5-methyl thiophene and cinnamaldehyde thiosemicarbazones and their palladium (II) complexes

EA Nyawade, NRS Sibuyi, M Meyer, R Lalancette… - Inorganica Chimica …, 2021 - Elsevier
New thiosemicarbazone (TSC) ligands, AMT-Cdouble bondN-TSCH (L1), AMT-Cdouble
bondN-TSC (CH 3)(L2), CIN-Cdouble bondN-TSCH (L3) and CIN-Cdouble bondN-TSC (CH …

Synthesis and antidiabetic evaluation of benzothiazole derivatives

G Mariappan, P Prabhat, L Sutharson… - Journal of the Korean …, 2012 - koreascience.kr
A novel series of benzothiazole derivatives were synthesized and assayed in vivo to
investigate their hypoglycemic activity by streptozotocin-induced diebetic model in rat. These …