Dose-response analysis can be carried out using multi-purpose commercial statistical
software, but except for a few special cases the analysis easily becomes cumbersome as …

Background Observational studies support a role for oral anticoagulation to reduce the risk
of dementia in atrial fibrillation patients, but conclusive data are lacking. Since dabigatran …

Background: Regular-fat cheese contains a high amount of saturated fat. Therefore, dietary
guidelines in many countries recommend the consumption of reduced-fat cheese as …

Purpose We investigated the effect of a person-centered intervention consisting of two to
four nurse-led conversations using guided self-determination tailored to gynecologic cancer …

In the European registration process, pesticides are currently mainly tested on the honey
bee. Since sensitivity data for other bee species are lacking for the majority of xenobiotics, it …

Background In clinical trials the study interest often lies in the comparison of a treatment to a
control regarding a time to event endpoint. A composite endpoint allows to consider several …

Background: With the increasing focus on obesity, growth patterns in infancy and early
childhood have gained much attention. Although the adiposity rebound has been in focus …

Many studies aim to assess whether a therapy has a beneficial effect on multiple outcomes
simultaneously relative to a control. Often the joint null hypothesis of no difference for the set …

When you write a book on statistics in toxicology you are sitting on the fence: For statisticians
much is known (or at least not exciting), but a large number of toxicologists will be …

In recent years germination experiments have become more and more complex. Typically,
they are replicated in time as independent runs and at each time point they involve …