Bacteria have long been the targets for genetic manipulation, but more recently they have
been synthetically designed to carry out specific tasks. Among the simplest of these tasks is …

Living organisms have evolved a plethora of sensing systems for the intra-and extracellular
detection of small molecules, ions or physical parameters. Several recent studies have …

Genetic regulatory proteins inducible by small molecules are useful synthetic biology tools
as sensors and switches. Bacterial allosteric transcription factors (aTFs) are a major class of …

Abstract Within the Design-Build-Test Cycle for strain engineering, rapid product detection
and selection strategies remain challenging and limit overall throughput. Here we …

Monitoring cellular behavior and eventually properly adapting cellular processes is key to
handle the enormous complexity of today's metabolic engineering questions. Hence …

The biosynthesis of short-chain alcohols is a carbon-neutral alternative to petroleum-derived
production, but strain screening operations are encumbered by laborious analytics. Here …

Genetically encoded biosensors have a diverse range of detectable signals and potential
applications in many fields, including metabolism control and high-throughput screening …

Prokaryotic transcriptional networks possess a large number of regulatory modules that
formally implement many of the logic gates that are typical of digital, Boolean circuits. Yet …

Transcriptional biosensors enable key applications in both metabolic engineering and
synthetic biology. Due to nature's immense variety of metabolites, these applications require …

From a biotechnological point of view, bacteria can be seen as either pathogens to target
with new drugs or as biocatalysts for large‐scale processes in industry, agriculture or the …