Neutrophils are the most abundant innate immune cell with critical anti-microbial functions.
Since the discovery of granulocytes at the end of the nineteenth century, the cells have been …

Neutrophils are versatile innate effector cells essential for immune defense but also
responsible for pathologic inflammation. This dual role complicates therapeutic targeting …

While fundamental in their innate role in combating infection and responding to injury,
neutrophils are emerging as key modulators of adaptive immune responses. Such functions …

The oral cavity is a complex environment constantly exposed to antigens from food and the
oral microbiota. Innate immune cells play an essential role in maintaining health and …

Background Septic shock occurs when sepsis is related to severe hypotension and leads to
a remarkable high number of deaths. The early diagnosis of septic shock is essential to …

Myeloproliferative disorders include several pathologies sharing the common feature of
being clonal hematopoietic stem cell diseases. The molecular basis of chronic myeloid …

Perturbations in immune processes are a hallmark of a number of autoimmune and
inflammatory disorders. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is …

Background Immune infiltration is implicated in the development of acquired resistance to
anti-angiogenic cancer therapy. We therefore investigated the correlation between …

Antineutrophil cytoplasmic antibodies (ANCAs) with specificity for proteinase 3 (PR3) are
central to a form of ANCA-associated vasculitis. Membrane PR3 (mPR3) is expressed only …

Polycythemia vera (PV) is a clonal disorder of unknown etiology involving a multipotent
hematopoietic progenitor cell that is characterized by the accumulation of phenotypically …