Over the past 25 years there have been thousands of published reports describing
applications of antisense nucleic acid derivatives for targeted inhibition of gene function. The …

▪ Abstract Since the discovery of enzymes as biological catalysts, study of their enormous
catalytic power and exquisite specificity has been central to biochemistry. Nevertheless …

The hammerhead ribozyme is a small catalytic RNA motif made up of three base-paired
stems and a core of highly conserved, non-complementary nucleotides essential for …

The hammerhead ribozyme (HHRz) is a small, naturally occurring ribozyme that site-
specifically cleaves RNA and has long been considered a potentially useful tool for gene …

A detailed biochemical and mechanistic study of in vitro selected variants of 8− 17
DNAzymes is presented. Even though the 8− 17 DNAzyme motif has been obtained through …

An updated, practical guide to bioinorganic chemistry Bioinorganic Chemistry: A Short
Course, Second Edition provides the fundamentals of inorganic chemistry and biochemistry …

Recent studies on the control of specific metabolic pathways in bacteria have documented
the existence of entirely RNA-based mechanisms for controlling gene expression. These …

The influence of chemical modifications on the catalytic activity and stability of a
hammerhead ribozyme directed against the long terminal repeat RNA of the human …

The hammerhead ribozyme is one of the smallest ribozymes known and catalyses the site‐
specific hydrolysis of a phosphodiester bond. This small ribozyme is of interest for two …

Natural hammerhead ribozymes are mostly found in some viroid and viroid‐like RNAs and
catalyze their cis cleavage during replication. Hammerheads have been manipulated to act …