Inside the diabetic brain: Insulin resistance and molecular mechanism associated with cognitive impairment and its possible therapeutic strategies

BJ Dutta, S Singh, S Seksaria, GD Gupta… - Pharmacological …, 2022 - Elsevier
Type 2 diabetes mellitus (T2DM) the most prevalent metabolic disease that has evolved into
a major public health issue. Concerning about its secondary complications, a growing body …

The role of glucagon-like peptide-1 receptor agonists (GLP-1 RA) in diabetes-related neurodegenerative diseases

D Cheng, S Yang, X Zhao, G Wang - Drug design, development …, 2023 - Taylor & Francis
Recent clinical guidelines have emphasized the importance of screening for cognitive
impairment in older adults with diabetes, however, there is still a lack of understanding about …

[HTML][HTML] Obesity-related cognitive impairment: The role of endothelial dysfunction

JJ Buie, LS Watson, CJ Smith, C Sims-Robinson - Neurobiology of Disease, 2019 - Elsevier
Obesity is a global pandemic associated with macro-and microvascular endothelial
dysfunction. Microvascular endothelial dysfunction has recently emerged as a significant risk …

From obesity to hippocampal neurodegeneration: pathogenesis and non-pharmacological interventions

TH Lee, S Yau - International journal of molecular sciences, 2020 - mdpi.com
High-caloric diet and physical inactivity predispose individuals to obesity and diabetes,
which are risk factors of hippocampal neurodegeneration and cognitive deficits. Along with …

Pathophysiology linking depression and type 2 diabetes: psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

R Subba, R Sandhir, SP Singh… - European Journal of …, 2021 - Wiley Online Library
Diabetes increases the likelihood of developing depression and vice versa. Research on
this bidirectional association has somewhat managed to delineate the interplay among …

Treadmill exercise mitigates neuroinflammation and increases BDNF via activation of SIRT1 signaling in a mouse model of T2DM

X Lang, N Zhao, Q He, X Li, X Li, C Sun, X Zhang - Brain Research Bulletin, 2020 - Elsevier
Although previous studies showed that exercise can improve cognitive dysfunction in type 2
diabetes (T2DM), the underlying mechanism remains unclear. Sirtuin 1 (SIRT1) has been …

Combined exercise training improves specific domains of cognitive functions and metabolic markers in middle-aged and older adults with type 2 diabetes mellitus

JG Silveira-Rodrigues, W Pires, PF Gomes… - Diabetes Research and …, 2021 - Elsevier
Aim To investigate the effects of 8-weeks of CT on specific domains of cognitive function,
metabolic and cardiovascular parameters of subjects with Type 2 Diabetes Mellitus (T2DM) …

Role of hippocampal lipocalin-2 in experimental diabetic encephalopathy

A Bhusal, MH Rahman, IK Lee, K Suk - Frontiers in endocrinology, 2019 - frontiersin.org
Diabetic encephalopathy is a severe diabetes-related complication in the central nervous
system (CNS) that is characterized by degenerative neurochemical and structural changes …

[HTML][HTML] Physical activity in a swimming pool attenuates memory impairment by reducing glutamate and inflammatory cytokines and increasing BDNF in the brain of …

M Shekarchian, M Peeri, MA Azarbayjani - Brain Research Bulletin, 2023 - Elsevier
Type 2 diabetes is a risk factor for the development of cognitive impairment. Increasing
evidence suggests that regular exercise is beneficial for the treatment of clinical symptoms in …

Potential of prevention strategies for the modifiable risk factor type 2 diabetes with relation to the future number of dementia patients in Germany–a multi-state …

A Fink, A Doerre, I Demuth, G Doblhammer - BMC neurology, 2022 - Springer
Background We assess the impact of prevention strategies regarding type 2 diabetes as a
modifiable risk factor for dementia and its consequences for the future number of dementia …