Coronaviruses are a large family of enveloped RNA viruses found in numerous animal species. They are well known for their ability to cross species barriers and have been …
ACM Boon, TL Bricker, EJ Fritch, SR Leist… - Journal of …, 2024 - Am Soc Microbiol
We developed a novel class of peptidomimetic inhibitors targeting several host cell human serine proteases, including transmembrane protease serine 2 (TMPRSS2), matriptase, and …
M El Sayes, R Badra, MA Ali, R El-Shesheny… - Zoonotic …, 2024 - mdpi.com
Simple Summary Bats are the second most diverse group of mammals in the world, with about 1400 different species, and they play an important role in both environmental and …
L Xia, Y Zhang, Q Zhou - Cell Research, 2024 - nature.com
Dear Editor, Human coronaviruses are pathogens capable of causing respiratory illnesses in humans, with seven identified species, 1 three of which have caused epidemics or global …
The human coronavirus HKU1 spike (S) glycoprotein engages host cell surface sialoglycans and transmembrane protease serine 2 (TMPRSS2) to initiate infection. The molecular basis …
A Adair, LL Tan, J Feng, J Girkin, N Bryant… - Journal of …, 2024 - Am Soc Microbiol
Human coronavirus (hCoV) OC43 is endemic to global populations and usually causes asymptomatic or mild upper respiratory tract illness. Here, we demonstrate the neutralization …
OD Ogunjinmi, T Abdullahi, RA Somji… - Journal of Medical …, 2024 - Wiley Online Library
The sex disparity in COVID‐19 outcomes with males generally faring worse than females has been associated with the androgen‐regulated expression of the protease TMPRSS2 …
V Siragam, M Maltseva, N Castonguay… - Microbiology …, 2024 - Am Soc Microbiol
The emergence of the COVID-19 pandemic prompted an increased interest in seasonal human coronaviruses. OC43, 229E, NL63, and HKU1 are endemic seasonal coronaviruses …
M Rexhepaj, YJ Park, L Perruzza, D Asarnow… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Porcine deltacoronavirus (PDCoV) spillovers were recently detected in children with acute undifferentiated febrile illness, underscoring recurrent zoonoses of divergent coronaviruses …