[HTML][HTML] Distinct evolution of SARS-CoV-2 Omicron XBB and BA. 2.86/JN. 1 lineages combining increased fitness and antibody evasion

D Planas, I Staropoli, V Michel, F Lemoine… - Nature …, 2024 - nature.com
The unceasing circulation of SARS-CoV-2 leads to the continuous emergence of novel viral
sublineages. Here, we isolate and characterize XBB. 1, XBB. 1.5, XBB. 1.9. 1, XBB. 1.16. 1 …

[HTML][HTML] Causes and Consequences of Coronavirus Spike Protein Variability

F Zech, C Jung, T Jacob, F Kirchhoff - Viruses, 2024 - mdpi.com
Coronaviruses are a large family of enveloped RNA viruses found in numerous animal
species. They are well known for their ability to cross species barriers and have been …

Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19

ACM Boon, TL Bricker, EJ Fritch, SR Leist… - Journal of …, 2024 - Am Soc Microbiol
We developed a novel class of peptidomimetic inhibitors targeting several host cell human
serine proteases, including transmembrane protease serine 2 (TMPRSS2), matriptase, and …

[HTML][HTML] Global Distribution and Molecular Evolution of Bat Coronaviruses

M El Sayes, R Badra, MA Ali, R El-Shesheny… - Zoonotic …, 2024 - mdpi.com
Simple Summary Bats are the second most diverse group of mammals in the world, with
about 1400 different species, and they play an important role in both environmental and …

[HTML][HTML] Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2

L Xia, Y Zhang, Q Zhou - Cell Research, 2024 - nature.com
Dear Editor, Human coronaviruses are pathogens capable of causing respiratory illnesses
in humans, with seven identified species, 1 three of which have caused epidemics or global …

Human coronavirus HKU1 recognition of the TMPRSS2 host receptor

M McCallum, YJ Park, C Stewart, KR Sprouse, J Brown… - bioRxiv, 2024 - biorxiv.org
The human coronavirus HKU1 spike (S) glycoprotein engages host cell surface sialoglycans
and transmembrane protease serine 2 (TMPRSS2) to initiate infection. The molecular basis …

Human coronavirus OC43 nanobody neutralizes virus and protects mice from infection

A Adair, LL Tan, J Feng, J Girkin, N Bryant… - Journal of …, 2024 - Am Soc Microbiol
Human coronavirus (hCoV) OC43 is endemic to global populations and usually causes
asymptomatic or mild upper respiratory tract illness. Here, we demonstrate the neutralization …

The antiviral potential of the antiandrogen enzalutamide and the viral‐androgen signaling interplay in seasonal coronaviruses

OD Ogunjinmi, T Abdullahi, RA Somji… - Journal of Medical …, 2024 - Wiley Online Library
The sex disparity in COVID‐19 outcomes with males generally faring worse than females
has been associated with the androgen‐regulated expression of the protease TMPRSS2 …

Seasonal human coronaviruses OC43, 229E, and NL63 induce cell surface modulation of entry receptors and display host cell-specific viral replication kinetics

V Siragam, M Maltseva, N Castonguay… - Microbiology …, 2024 - Am Soc Microbiol
The emergence of the COVID-19 pandemic prompted an increased interest in seasonal
human coronaviruses. OC43, 229E, NL63, and HKU1 are endemic seasonal coronaviruses …

[HTML][HTML] Broadly neutralizing antibodies against emerging delta-coronaviruses

M Rexhepaj, YJ Park, L Perruzza, D Asarnow… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Porcine deltacoronavirus (PDCoV) spillovers were recently detected in children with acute
undifferentiated febrile illness, underscoring recurrent zoonoses of divergent coronaviruses …