Background: Depression is the most debilitating neuropsychiatric disorder with significant
impact on socio-occupational and well being of individual. The exact pathophysiology of …

Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …

We used the 10x Genomics Visium platform to define the spatial topography of gene
expression in the six-layered human dorsolateral prefrontal cortex. We identified extensive …

Mitochondrial transport along microtubules is mediated by Miro1 and TRAK adaptors that
recruit kinesin-1 and dynein-dynactin. To understand how these opposing motors are …

Neurons display extreme degrees of polarization, including compartment-specific organelle
morphology. In cortical, long-range projecting, pyramidal neurons (PNs), dendritic …

Mitochondrial electron transport generates the ATP that is essential for the excitability and
survival of neurons, and the protein phosphorylation reactions that mediate synaptic …

The proper intracellular distribution of mitochondria is assumed to be critical for normal
physiology of neuronal cells, but direct evidence for this idea is lacking. Extension or …

Summary PTEN-induced kinase 1 (PINK1) is a short-lived protein required for the removal of
damaged mitochondria through Parkin translocation and mitophagy. Because the short half …

Mitochondria are mobile organelles and cells regulate mitochondrial movement in order to
meet the changing energy needs of each cellular region. Ca 2+ signaling, which halts both …

Mitochondria are central for various cellular processes that include ATP production,
intracellular Ca2+ signaling, and generation of reactive oxygen species. Neurons critically …