Background: For many years triptans have been the cornerstone of acute migraine
treatment. Nevertheless, treatment with triptans may not always be initiated due to …

Background This study investigated the mechanism of action of atogepant, a small-molecule
CGRP receptor antagonist recently approved for the preventive treatment of episodic …

Calcitonin gene-related peptide (CGRP)-antagonizing drugs represent a major advance in
migraine treatment. However, up to 50% of patients do not benefit from monoclonal …

We aimed to investigate a sexually dimorphic role of calcitonin gene-related peptide (CGRP)
in rodent models of pain. Based on findings in migraine where CGRP has a preferential pain …

Calcitonin-gene-related peptide (CGRP) plays a key role in migraine pathophysiology and
more specifically in the mechanisms underlying peripheral and central sensitization. Here …

Background Knowledge of exact signalling events during migraine attacks is lacking.
Various substances are known to trigger migraine attacks in patients and calcitonin gene …

Recently, we showed that while atogepant-a small-molecule calcitonin gene-related peptide
(CGRP) receptor antagonist-does not fully prevent activation of nociceptors, it significantly …

Sleep deprivation can trigger migraine, and migraineurs often choose to sleep to relieve
headaches during acute migraine. This study aimed to explore the effect of acute sleep …

Background Migraine research has highlighted the pivotal role of nitric oxide (NO) in
migraine pathophysiology. Nitric oxide donors such as glyceryl trinitrate (GTN) induce …

Migraine has a high prevalence worldwide and is one of the main disabling neurological
diseases in individuals under the age of 50. In general, treatment includes the use of oral …