Epilepsy refers to a common chronic neurological disorder that affects all age groups.
Unfortunately, antiepileptic drugs are ineffective in about one-third of patients. The complex …

Epilepsy is one of the most prevalent neurologic conditions, affecting almost 70 million
people worldwide. In the United States, 1.3 million women with epilepsy (WWE) are in their …

The ATP-binding cassette family of transporter proteins, subfamily B (MDR/TAP), member 1
(ABCB1)(P-glycoprotein) transporter is a key component of the blood–brain barrier. Many …

Aims: Some study found that ATP‐binding cassette (ABC) efflux transporters play an
important role in antiepileptic drug resistance, especially ABCB1 and ABCC2. The aims of …

Aim: The present study aimed to evaluate the effects of SNPs of major transporter and
metabolizing enzyme genes on carbamazepine (CBZ) metabolism in Chinese patients with …

Drug resistance is common in epilepsy despite multiple available medications. Single
nucleotide polymorphisms (SNP) may influence drug efficacy in epilepsy. We therefore …

Pharmacogenetic factors may play an important role in drug-resistant epilepsy. The
association between the non-synonymous polymorphism G2677T/A in the coding region of …

Purpose This study aims to evaluate the associations between genetic polymorphisms and
the effect of sodium valproate (VPA) therapy in children with generalized seizures. Methods …

Purpose Epilepsy is a common serious brain condition characterized by the abnormal
electrical activity of neurons. In most cases, epileptic patients respond to antiepileptic drugs …

Background: Valproic acid (VPA) is a widely used antiepileptic drug with acceptable safety
and efficacy in treating pediatric patients with various kinds of seizures. However …