Mechanistic links between obesity, diabetes, and blood pressure: role of perivascular adipose tissue

SN Saxton, BJ Clark, SB Withers… - Physiological …, 2019 - journals.physiology.org
Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Nrf2 as a potential mediator of cardiovascular risk in metabolic diseases

RM da Costa, D Rodrigues, CA Pereira… - Frontiers in …, 2019 - frontiersin.org
Free radicals act as secondary messengers, modulating a number of important biological
processes, including gene expression, ion mobilization in transport systems, protein …

Perivascular adipose tissue regulates vascular function by targeting vascular smooth muscle cells

L Chang, MT Garcia-Barrio, YE Chen - … , thrombosis, and vascular …, 2020 - Am Heart Assoc
Adipose tissues are present at multiple locations in the body. Most blood vessels are
surrounded with adipose tissue which is referred to as perivascular adipose tissue (PVAT) …

PVAT and its relation to brown, beige, and white adipose tissue in development and function

S Hildebrand, J Stümer, A Pfeifer - Frontiers in Physiology, 2018 - frontiersin.org
Adipose tissue is commonly categorized into three types with distinct functions, phenotypes,
and anatomical localizations. White adipose tissue (WAT) is the major energy store; the …

[HTML][HTML] Perivascular adipose tissue: Fine-tuner of vascular redox status and inflammation

CK Cheng, H Ding, M Jiang, H Yin, M Gollasch… - Redox Biology, 2023 - Elsevier
Perivascular adipose tissue (PVAT) refers to the aggregate of adipose tissue surrounding
the vasculature, exhibiting the phenotypes of white, beige and brown adipocytes. PVAT has …

[HTML][HTML] The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives

AB Behrooz, M Cordani, A Fiore, M Donadelli… - Seminars in Cancer …, 2024 - Elsevier
Autophagy, a self-degradative process vital for cellular homeostasis, plays a significant role
in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex …

The interplay between adipose tissue and vasculature: Role of oxidative stress in obesity

Y Zhou, H Li, N Xia - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Cardiovascular diseases (CVDs) rank the leading cause of morbidity and mortality globally.
Obesity and its related metabolic syndrome are well-established risk factors for CVDs …

Perivascular adipose tissue as a relevant fat depot for cardiovascular risk in obesity

RM Costa, KB Neves, RC Tostes, NS Lobato - Frontiers in physiology, 2018 - frontiersin.org
Obesity is associated with increased risk of premature death, morbidity, and mortality from
several cardiovascular diseases (CVDs), including stroke, coronary heart disease (CHD) …

Perivascular adipose tissue and vascular smooth muscle tone: friends or foes?

A Ahmed, A Bibi, M Valoti, F Fusi - Cells, 2023 - mdpi.com
Perivascular adipose tissue (PVAT) is a specialized type of adipose tissue that surrounds
most mammalian blood vessels. PVAT is a metabolically active, endocrine organ capable of …

Anti-inflammatory effects of melatonin in obesity and hypertension

NJ Prado, L Ferder, W Manucha, ER Diez - Current hypertension reports, 2018 - Springer
Abstract Purpose of Review Here, we review the known relations between hypertension and
obesity to inflammation and postulate the endogenous protective effect of melatonin and its …