Neuroactive steroids are natural or synthetic steroids that rapidly alter the excitability of
neurons by binding to membrane‐bound receptors such as those for inhibitory and (or) …

Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

GABAA‐receptors display an extensive structural heterogeneity based on the differential
assembly of a family of at least 15 subunits (α1–6, β1–3, γ1–3, θ, ρl–2) into distinct …

Dispersion of tumors throughout the body is a neoplastic process responsible for the vast
majority of deaths from cancer. Despite disseminating to distant organs as malignant scouts …

Inhibitory neurotransmission in the brain is largely mediated by GABA A receptors.
Potentiation of GABA receptor activation through an allosteric benzodiazepine (BZ) site …

Benzodiazepines are widely used clinically to treat anxiety and insomnia. They also induce
muscle relaxation, control epileptic seizures, and can produce amnesia. Moreover …

Neuroactive steroids are potent modulators of γ-aminobutyric acid type A receptors
(GABAARs), and their behavioral effects are generally viewed in terms of altered inhibitory …

The amino acid γ-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotrans-
mitter that mediates most of its effects through fast GABA-gated Cl−-channels (GABA AR) …

Neurotransmitter receptor systems have been the focus of intensive pharmacological
research for more than 20 years for basic and applied scientific reasons, but only recently …

Benzodiazepines (BZ) modulate neurotransmitter-evoked chloride currents at the gamma-
aminobutyric acid type A (GABAA) receptor, the major inhibitory ion channel in the …