In recent years, powerful genetic code reprogramming methods have emerged that allow
new functional components to be embedded into proteins as noncanonical amino acid …

Our understanding of the complex molecular processes of living organisms at the molecular
level is growing exponentially. This knowledge, together with a powerful arsenal of tools for …

The two main strategies for enzyme engineering, directed evolution and rational design,
have found widespread applications in improving the intrinsic activities of proteins. Although …

Within the canonical repertoire of the amino acid involved in protein biogenesis, proline
plays a unique role as an amino acid presenting a modified backbone rather than a side …

Competitive sustainable production in industry demands new and better biocatalysts,
optimized bioprocesses and cost-effective product recovery. Our review sheds light on the …

Chiral amines are important components of 40–45% of small molecule pharmaceuticals and
many other industrially important fine chemicals and agrochemicals. Recent advances in …

The goal of xenobiology is to design biological systems endowed with unusual biochemical
functions, whereas enzymology concerns the study of enzymes, the workhorses of …

Improvement in intrinsic enzymatic features is in many instances a prerequisite for the
scalable applicability of many industrially important biocatalysts. To this end, various …

Biocatalysis has become an important component of modern organic chemistry, presenting
an efficient and environmentally friendly approach to synthetic transformations. Advances in …

Unnatural amino acids have gained significant attention in protein engineering and drug
discovery as they allow the evolution of proteins with enhanced stability and activity. The …