Bacteria in the genus Brucella are important human and veterinary pathogens. The abortion
and infertility they cause in food animals produce economic hardships in areas where the …

Cyclic adenosine diphosphate (ADP)–ribose (cADPR) isomers are signaling molecules
produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide …

Members of the genus Brucella are the causative agents of brucellosis, a worldwide
zoonosis affecting wild and domestic animals and humans. These facultative intracellular …

Brucella species are facultative intracellular Gram-negative bacteria relevant to animal and
human health. Their ability to establish an intracellular niche and subvert host cell pathways …

Brucellosis is a highly contagious zoonosis that occurs worldwide. Whole-genome
sequencing (WGS) has become a widely accepted molecular typing method for outbreak …

Toll/interleukin-1 receptor (TIR) domains in Toll-like receptors are essential for initiating and
propagating the eukaryotic innate immune signaling cascade. Here, we investigate TirS, a …

Bacterial pathogens often subvert the innate immune system to establish a successful
infection. The direct inhibition of downstream components of innate immune pathways is …

Host engulfment protein ELMO1 generates intestinal inflammation following internalization
of enteric bacteria. In Shigella, bacterial effector IpgB1 interacts with ELMO1 and promotes …

Nicotinamide adenine dinucleotide (NAD+) is a major cofactor in redox reactions in all life-
forms. A stable level of NAD+ is vital to ensure cellular homeostasis. Some pathogens can …

The facultative intracellular pathogen Brucella and the free-living bacteria Ochrobactrum are
both α-proteobacteria and very close to each other. A group of researchers recently …