The key role of p53 as a tumor suppressor became clear when it was realized that this gene
is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to …

As a tumor suppressor and the most frequently mutated gene in cancer, p53 is among the
best-described molecules in medical research. As cancer is in most cases an age-related …

Contemporary studies on aging and longevity have largely overlooked the role that
adaptation plays in lifespan variation across species. Emerging evidence indicates that the …

Cellular aging is considered as one of the main factors implicated in female infertility. We
evaluated the expression of senescence-associated secretory phenotype (SASP) markers …

Simple Summary Glioblastoma multiforme (GBM) is a highly invasive brain tumor that
typically has poor patient outcomes. This is due in part to aggressive tumor expansion within …

The many limitations of implementing anticancer strategies under the term “precision
oncology” have been extensively discussed. While some authors propose promising future …

Cardiorenal syndrome (CRS) denotes the bidirectional interaction of chronic kidney disease
and heart failure with an adverse prognosis but with a limited understanding of its …

Cellular aging is considered as one of the main factors leading to female infertility. The
process called “inflammaging”, which was proposed by C. Franceschi in 2014 is …

In this thesis, I have explored the role of three genes related to p53, namely p21, MDM2 and
MDMX, in regulating ferroptosis, a form of non-apoptotic cell death. Ferroptosis, an iron …

This work received financial support from PT national funds (FCT/MCTES, Fundação para a
Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through …