Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …

Abstract High-conductance,'big'potassium (BK) channels encoded by the Slo gene family
are among the largest and most complex of the extended family of potassium channels. The …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

Ethanol produces a wide variety of behavioral and physiological effects in the body, but
exactly how it acts to produce these effects is still poorly understood. Although ethanol was …

Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In
particular, activation of calcium-and voltage-gated potassium channels of large conductance …

Alcohol use and abuse appear to be related to neuroadaptive changes at functional,
neurochemical, and structural levels. Acute and chronic ethanol exposure have been shown …

Glioblastoma multiforme is the most common and lethal primary brain cancer in adults.
Tumor cells diffusely infiltrate the brain making focal surgical and radiation treatment …

Hydrogen sulfide (H 2 S) is the third gasotransmitter found to be produced endogenously in
living cells to exert physiological functions. Large conductance (maxi) calcium-activated …

Chronic alcohol exposure can cause dramatic behavioral alterations, including increased
anxiety-like behavior and depression. These alterations are proposed to be due in part to …

Alcoholism is a complex psychiatric disorder that has a multifactorial etiology. Epigenetic
mechanisms are uniquely capable of accounting for the multifactorial nature of the disease …