Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond

L Calderón-Garcidueñas, E Leray, P Heydarpour… - Revue …, 2016 - Elsevier
Air pollution (indoors and outdoors) is a major issue in public health as epidemiological
studies have highlighted its numerous detrimental health consequences (notably …

Exploiting intrinsic nanoparticle toxicity: the pros and cons of nanoparticle-induced autophagy in biomedical research

K Peynshaert, BB Manshian, F Joris… - Chemical …, 2014 - ACS Publications
1. INTRODUCTION In his 1959 keynote lecture “There is plenty of room at the bottom”,
Richard Feynman introduced the concepts that would later form the basis of a new era of …

Central nervous system toxicity of metallic nanoparticles

X Feng, A Chen, Y Zhang, J Wang… - International journal of …, 2015 - Taylor & Francis
Nanomaterials (NMs) are increasingly used for the therapy, diagnosis, and monitoring of
disease-or drug-induced mechanisms in the human biological system. In view of their small …

Prefrontal white matter pathology in air pollution exposed Mexico City young urbanites and their potential impact on neurovascular unit dysfunction and the …

L Calderón-Garcidueñas, R Reynoso-Robles… - Environmental …, 2016 - Elsevier
Millions of urban children are chronically exposed to high concentrations of air pollutants, ie,
fine particulate matter (PM 2.5) and ozone, associated with increased risk for Alzheimer's …

The use of medicinal plant-derived metallic nanoparticles in theranostics

JH Xulu, T Ndongwe, KM Ezealisiji, VJ Tembu… - Pharmaceutics, 2022 - mdpi.com
In the quest to effectively diagnose and treat the diseases that afflict mankind, the
development of a tool capable of simultaneous detection and treatment would provide a …

Air pollution and children: neural and tight junction antibodies and combustion metals, the role of barrier breakdown and brain immunity in neurodegeneration

L Calderón-Garcidueñas, A Vojdani… - Journal of …, 2014 - journals.sagepub.com
Millions of children are exposed to concentrations of air pollutants, including fine particulate
matter (PM2. 5), above safety standards. In the Mexico City Metropolitan Area (MCMA) …

Megacities air pollution problems: Mexico City Metropolitan Area critical issues on the central nervous system pediatric impact

L Calderón-Garcidueñas, RJ Kulesza, RL Doty… - Environmental …, 2015 - Elsevier
The chronic health effects associated with sustained exposures to high concentrations of air
pollutants are an important issue for millions of megacity residents and millions more living …

Opportunities for nitric oxide in potentiating cancer immunotherapy

J Kim, SN Thomas, M Michel - Pharmacological Reviews, 2022 - Elsevier
Despite nearly 30 years of development and recent highlights of nitric oxide (NO) donors
and NO delivery systems in anticancer therapy, the limited understanding of exogenous …

Silver nanoparticles induce tight junction disruption and astrocyte neurotoxicity in a rat blood–brain barrier primary triple coculture model

L Xu, M Dan, A Shao, X Cheng, C Zhang… - International journal …, 2015 - Taylor & Francis
Background Silver nanoparticles (Ag-NPs) can enter the brain and induce neurotoxicity.
However, the toxicity of Ag-NPs on the blood–brain barrier (BBB) and the underlying …

Combustion-derived nanoparticles in key brain target cells and organelles in young urbanites: culprit hidden in plain sight in Alzheimer's disease development

A González-Maciel, R Reynoso-Robles… - Journal of …, 2017 - content.iospress.com
Millions of children and young adults are exposed to fine particulate matter (PM 2.5) and
ozone, associated with Alzheimer's disease (AD) risk. Mexico City (MC) children exhibit …