Transforming growth factor-β regulation of immune responses
Transforming growth factor-β (TGF-β) is a potent regulatory cytokine with diverse effects on
hemopoietic cells. The pivotal function of TGF-β in the immune system is to maintain …
hemopoietic cells. The pivotal function of TGF-β in the immune system is to maintain …
TGF-β–an excellent servant but a bad master
L Kubiczkova, L Sedlarikova, R Hajek… - Journal of translational …, 2012 - Springer
The transforming growth factor (TGF-β) family of growth factors controls an immense number
of cellular responses and figures prominently in development and homeostasis of most …
of cellular responses and figures prominently in development and homeostasis of most …
Regulatory T cell plasticity and stability and autoimmune diseases
R Qiu, L Zhou, Y Ma, L Zhou, T Liang, L Shi… - Clinical reviews in …, 2020 - Springer
Abstract CD4+ CD25+ regulatory T cells (Tregs) are a class of CD4+ T cells with
immunosuppressive functions that play a critical role in maintaining immune homeostasis …
immunosuppressive functions that play a critical role in maintaining immune homeostasis …
Transforming growth factor beta in cardiovascular development and function
M Azhar, JEJ Schultz, I Grupp, GW Dorn II… - Cytokine & growth factor …, 2003 - Elsevier
Transforming growth factor betas (TGFβs) are pleiotropic cytokines involved in many
biological processes. Genetic engineering and tissue explanation studies have revealed …
biological processes. Genetic engineering and tissue explanation studies have revealed …
Influence of genetic background on genetically engineered mouse phenotypes
T Doetschman - Gene Knockout Protocols: Second Edition, 2009 - Springer
The history of mouse genetics, which involves the study of strain-dependent phenotype
variability, makes it clear that the genetic background onto which a gene-targeted allele is …
variability, makes it clear that the genetic background onto which a gene-targeted allele is …
TGF-β1 uses distinct mechanisms to inhibit IFN-γ expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet
JT Lin, SL Martin, L Xia, JD Gorham - The Journal of Immunology, 2005 - journals.aai.org
TGF-β1 plays a critical role in restraining pathogenic Th1 autoimmune responses in vivo, but
the mechanisms that mediate TGF-β1's suppressive effects on CD4+ T cell expression of IFN …
the mechanisms that mediate TGF-β1's suppressive effects on CD4+ T cell expression of IFN …
Infectious tolerance and the long‐term acceptance of transplanted tissue
H Waldmann, E Adams, P Fairchild… - Immunological …, 2006 - Wiley Online Library
Short courses of antibody treatment aimed at blocking the coreceptors CD4 and CD8 and/or
costimulatory molecules such as CD40L are able to bring about long‐term acceptance and …
costimulatory molecules such as CD40L are able to bring about long‐term acceptance and …
TGFβ1 and Treg cells: alliance for tolerance
R Bommireddy, T Doetschman - Trends in molecular medicine, 2007 - cell.com
Transforming growth factor β1 (TGFβ1), an important pleiotropic, immunoregulatory cytokine,
uses distinct signaling mechanisms in lymphocytes to affect T-cell homeostasis, regulatory T …
uses distinct signaling mechanisms in lymphocytes to affect T-cell homeostasis, regulatory T …
Developmental differences in microglia morphology and gene expression during normal brain development and in response to hypoxia-ischemia
P Cengiz, D Zafer, JH Chandrashekhar… - Neurochemistry …, 2019 - Elsevier
Background Neuroinflammation plays an important role in ischemic brain injury and
recovery, however the interplay between brain development and the neuroinflammatory …
recovery, however the interplay between brain development and the neuroinflammatory …
Regulatory T cells in transplantation
Our ability to harness tolerance mechanisms will have a major impact in organ
transplantation. It should enable drug minimization, and eventually, the elimination of all …
transplantation. It should enable drug minimization, and eventually, the elimination of all …