Evidence suggests that uncontrolled immune system responses and their components play
a significant role in developing rheumatoid arthritis (RA), which is considered an …

Despite an increasing burden of osteoarthritis in developed societies, target discovery has
been slow and there are currently no approved disease-modifying osteoarthritis drugs. This …

Ferroptosis is an iron‐dependent cell death that has been found to aggravate the
progression of osteoarthritis (OA) and gut microbiota‐OA axis refers to the bidirectional …

Background Pain is reported as the leading cause of disability in the common forms of
inflammatory arthritis conditions. Acting as a key player in nociceptive processing …

Gut microbiota dysbiosis has been studied under the pathological conditions of osteoarthritis
(OA). However, the effect of antibiotic-induced gut flora dysbiosis on OA remains …

The synovium of osteoarthritis (OA) patients can be characterized by an abnormal
accumulation of macrophages originating from extravasated monocytes. Since targeting …

In this narrative review, we discuss the emerging role of innate immunity in osteoarthritis
(OA) joint pain. First, we give a brief description of the pain pathway in the context of OA …

Abstract Purpose of Review Osteoarthritis (OA) is the most common form of arthritis and a
major source of pain and disability worldwide. OA-associated pain is usually refractory to …

Summary This Year in Review was derived from a personal selection of articles investigating
biological mechanisms of osteoarthritis (OA) and presented at the OARSI World Congress …

Osteoarthritis (OA) is a prevalent degenerative disease accompanied by the activation of
innate and adaptive immune systems-associated inflammatory responses. Due to the local …