The dark side of stemness–the role of hematopoietic stem cells in development of blood malignancies
J Filipek-Gorzała, P Kwiecińska, A Szade… - Frontiers in …, 2024 - frontiersin.org
Hematopoietic stem cells (HSCs) produce all blood cells throughout the life of the organism.
However, the high self-renewal and longevity of HSCs predispose them to accumulate …
However, the high self-renewal and longevity of HSCs predispose them to accumulate …
Characterization of the Intraclonal Complexity of Chronic Lymphocytic Leukemia B Cells: Potential Influences of B-Cell Receptor Crosstalk with Other Stimuli
AN Mazzarello, M Fitch, M Cardillo, A Ng, S Bhuiya… - Cancers, 2023 - mdpi.com
Simple Summary Chronic lymphocytic leukemia (CLL) clones contain cells differing in age:
recently born, proliferative (PF), intermediate (IF), and resting (RF) fractions. We used …
recently born, proliferative (PF), intermediate (IF), and resting (RF) fractions. We used …
The multi-faceted roles of MYC in the prognosis of chronic lymphocytic leukemia
L Ysebaert, PL Mouchel, C Laurent… - Leukemia & …, 2024 - Taylor & Francis
In this review, we focus on the pro-oncogene MYC, the modes of deregulation in mouse and
human B-cells, its undisputable importance in the evaluation of biological prognostication of …
human B-cells, its undisputable importance in the evaluation of biological prognostication of …
[HTML][HTML] Large-scale assessment of pros and cons of autopsy-derived or tumor-matched tissues as the norms for gene expression analysis in cancers
Normal tissues are essential for studying disease-specific differential gene expression.
However, healthy human controls are typically available only in postmortal/autopsy settings …
However, healthy human controls are typically available only in postmortal/autopsy settings …
Normal B cells express ZAP70 in chronic lymphocytic leukemia: A link between autoimmunity and lymphoproliferation?
D Ghergus, M Martin, A Knapp… - American Journal of …, 2024 - Wiley Online Library
ZAP70 has a prognostic value in chronic lymphocytic leukemia (CLL), through altered B‐cell
receptor signaling, which is important in CLL pathogenesis. A good correlation between …
receptor signaling, which is important in CLL pathogenesis. A good correlation between …
B cell receptor signaling proteins as biomarkers for progression of CLL requiring first-line therapy
MYL Vervoordeldonk, PJ Hengeveld… - Leukemia & …, 2024 - Taylor & Francis
The molecular landscape of chronic lymphocytic leukemia (CLL) has been extensively
characterized, and various potent prognostic biomarkers were discovered. The genetic …
characterized, and various potent prognostic biomarkers were discovered. The genetic …
[HTML][HTML] Persistent B-Cell Stimulation or B-Cell Repertoire Anomalies? The Dilemma of the Origin of Chronic Lymphocytic Leukemia (CLL)
Lymphatics | Free Full-Text | Persistent B-Cell Stimulation or B-Cell Repertoire Anomalies?
The Dilemma of the Origin of CLL Previous Article in Journal Prevalence and Quality of Life …
The Dilemma of the Origin of CLL Previous Article in Journal Prevalence and Quality of Life …
[HTML][HTML] Impending splenic rupture as indicator of atypical chronic lymphocytic leukemia: A case report from Saudi Arabia
RY Al-Ansari, H Al-Rayes, LM Abdalla… - International Journal of …, 2023 - Elsevier
Background Chronic lymphocytic leukemia (CLL) is one of the hematological malignancies
in which the bone marrow overproduces mature, dysfunctional lymphocytes. Affected …
in which the bone marrow overproduces mature, dysfunctional lymphocytes. Affected …
Unexpected CD5+ B Cell Lymphocytosis during SARS-CoV-2 Infection: Relevance for the Pathophysiology of Chronic Lymphocytic Leukemia
AN Mazzarello, B Koroveshi, D Guardo… - Journal of Clinical …, 2023 - mdpi.com
Recently, cases of fortuitous discovery of Chronic Lymphocytic Leukemia (CLL) during
hospitalization for Coronavirus disease (COVID-19) have been reported. These patients did …
hospitalization for Coronavirus disease (COVID-19) have been reported. These patients did …
Evidence that chronic lymphocytic leukemia arises from a multiclonal selection process
D Bagnara, N Cardente, S Vergani, S Kasar… - 2024 - researchsquare.com
Although chronic lymphocytic leukemia (CLL) is diagnosed by identifying in a patient's blood
a B-cell clone that exceeds 5x10 6/µL, additional clones have on occasion been identified …
a B-cell clone that exceeds 5x10 6/µL, additional clones have on occasion been identified …